Tissue morphogenesis requires the collective, coordinated motion and deformation of a
large number of cells. Vertex model simulations for tissue mechanics have been developed …

The dynamic behavior of epithelial cell sheets plays a central role during numerous
developmental processes. Genetic and imaging studies of epithelial morphogenesis in a …

This monograph presents a general mathematical theory for biological growth. It provides
both a conceptual and a technical foundation for the understanding and analysis of …

The physical and mechanical properties of the cellular microenvironment regulate cell
shape and can strongly influence cell fate. How mechanical cues are sensed and …

The Drosophila wing imaginal disc is a tissue of undifferentiated cells that are precursors of
the wing and most of the notum of the adult fly. The wing disc first forms during …

The seminal observation that mechanical signals can elicit changes in biochemical
signalling within cells, a process commonly termed mechanosensation and …

Mechanical forces have been proposed to modulate organ growth, but a molecular
mechanism that links them to growth regulation in vivo has been lacking. We report that …

Control of cell proliferation is a fundamental aspect of tissue physiology central to
morphogenesis, wound healing, and cancer. Although many of the molecular genetic factors …

The coordinated behaviour of populations of cells plays a central role in tissue growth and
renewal. Cells react to their microenvironment by modulating processes such as movement …

The presence of diffuse morphogen gradients in tissues supports a view in which growth is
locally homogenous. Here we challenge this view: we used a high-resolution quantitative …