Alzheimer's disease (AD) is a devastating neurodegenerative disorder without a cure. Most
AD cases are sporadic where age represents the greatest risk factor. Lack of understanding …

Alzheimer's disease (AD) is a prevalent neurodegenerative disease characterized by both
amnestic and non-amnestic clinical manifestations. It accounts for approximately 60-70% of …

Alzheimer's disease (AD) is an age-related neurodegenerative disorder. Although an
accumulation of brain amyloid-β (Aβ) peptide and hyperphosphorylated tau protein have …

An important concept in neurobiology is “neurons that fire together, wire together” which
means that the formation and maintenance of synapses is promoted by activation of those …

Alzheimer's Disease (AD) currently affects more than 5 million Americans, with numbers
expected to grow dramatically as the population ages. The pathophysiological changes in …

Protein aggregation is the hallmark of several neurodegenerative disorders. These protein
aggregation (fibrillization) disorders are also known as amyloid disorders. The mechanism …

The multifunctional protein, voltage-dependent anion channel 1 (VDAC1), is located on the
mitochondrial outer membrane. It is a pivotal protein that maintains mitochondrial function to …

Peroxisome proliferator-activated receptor (PPAR) β/δ belongs to the family of hormone and
lipid-activated nuclear receptors, which are involved in metabolism of long-chain fatty acids …

Alzheimer's disease (AD) is a progressive neurodegenerative disease that represents the
most common form of dementia among the elderly. Despite the fact that AD was studied for …

Alzheimer's disease (AD) is characterized by the formation of senile plaques and
neurofibrillary tangles composed of phosphorylated Tau. Several findings suggest that …