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Physiology and pathophysiology of human airway mucus
DB Hill, B Button, M Rubinstein… - Physiological …, 2022 - journals.physiology.org
The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …
Muco-obstructive lung diseases
RC Boucher - New England Journal of Medicine, 2019 - Mass Medical Soc
Muco-Obstructive Lung Diseases This review covers the normal mechanisms of mucus
formation and how they are abnormal in common conditions—such as COPD, cystic fibrosis …
formation and how they are abnormal in common conditions—such as COPD, cystic fibrosis …
The commensal lifestyle of Staphylococcus aureus and its interactions with the nasal microbiota
B Krismer, C Weidenmaier, A Zipperer… - Nature reviews …, 2017 - nature.com
Although human colonization by facultative bacterial pathogens, such as Staphylococcus
aureus, represents a major risk factor for invasive infections, the commensal lifestyle of such …
aureus, represents a major risk factor for invasive infections, the commensal lifestyle of such …
Lysozymes in the animal kingdom
L Callewaert, CW Michiels - Journal of biosciences, 2010 - Springer
Abstract Lysozymes (EC 3.2. 1.17) are hydrolytic enzymes, characterized by their ability to
cleave the β-(1, 4)-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine …
cleave the β-(1, 4)-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine …
Pathophysiology and management of pulmonary infections in cystic fibrosis
RL Gibson, JL Burns, BW Ramsey - American journal of respiratory …, 2003 - atsjournals.org
This comprehensive State of the Art review summarizes the current published knowledge
base regarding the pathophysiology and microbiology of pulmonary disease in cystic …
base regarding the pathophysiology and microbiology of pulmonary disease in cystic …
Antiviral mechanisms of human defensins
SS Wilson, ME Wiens, JG Smith - Journal of molecular biology, 2013 - Elsevier
Defensins are an effector component of the innate immune system with broad antimicrobial
activity. Humans express two types of defensins, α-and β-defensins, which have antiviral …
activity. Humans express two types of defensins, α-and β-defensins, which have antiviral …
Role of teichoic acids in Staphylococcus aureus nasal colonization, a major risk factor in nosocomial infections
C Weidenmaier, JF Kokai-Kun, SA Kristian… - Nature medicine, 2004 - nature.com
Colonization of the anterior nares in∼ 37% of the population is a major risk factor for severe
Staphylococcus aureus infections. Here we show that wall teichoic acid (WTA), a surface …
Staphylococcus aureus infections. Here we show that wall teichoic acid (WTA), a surface …
Staphylococcus aureus virulence factors in evasion from innate immune defenses in human and animal diseases
In the last decades, Staphylococcus aureus acquired a dramatic relevance in human and
veterinary medicine for different reasons, one of them represented by the increasing …
veterinary medicine for different reasons, one of them represented by the increasing …
pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37
MH Abou Alaiwa, LR Reznikov, ND Gansemer… - Proceedings of the …, 2014 - pnas.org
The pulmonary airways are continuously exposed to bacteria. As a first line of defense
against infection, the airway surface liquid (ASL) contains a complex mixture of antimicrobial …
against infection, the airway surface liquid (ASL) contains a complex mixture of antimicrobial …
Pseudomonas aeruginosa: Host defence in lung diseases
BJ Williams, J Dehnbostel, TS Blackwell - Respirology, 2010 - Wiley Online Library
Lung infections caused by the opportunistic pathogen Pseudomonas aeruginosa can
present as a spectrum of clinical entities from a rapidly fatal pneumonia in a neutropenic …
present as a spectrum of clinical entities from a rapidly fatal pneumonia in a neutropenic …