Active drug efflux transporters of the ATP binding cassette (ABC)-containing family of
proteins have a major impact on the pharmacological behavior of most of the drugs in use …

In recent years, there has been an increased understanding of P-glycoprotein (P-GP)-
mediated pharmacokinetic interactions. In addition, its role in modifying the bioavailability of …

The mouse mdr1a (also called mdr3) P-GP is abundant in the blood-brain barrier, and its
absence in mdr1a (-/-) mice leads to highly increased levels of the drugs ivermectin …

We have previously shown that absence of the mouse mdr1a (also called mdr3) P-
glycoprotein in mdr1a (-/-)" knockout" mice has a profound effect on the tissue distribution …

The drug efflux transporters ABCB1 and ABCG2 at the blood-brain barrier limit the delivery
of drugs into the brain. Strategies to overcome ABCB1/ABCG2 have been largely …

One of the major problems related with anticancer chemotherapy is resistance against
anticancer drugs. The ATP-binding cassette (ABC) transporters are a family of transporter …

The multidrug resistance-associated protein (MRP) is the product of an ATP-binding
cassette transporter gene overexpressed in some tumor cells resistant to antineoplastic …

P-glycoprotein (also known as multidrug resistance protein 1 (MDR1) or ATP-binding
cassette sub-family B member 1 (ABCB1) plays a crucial role in determining response …

The membrane proteins mediating the ATP-dependent transport of lipophilic substances
conjugated to glutathione, glucuronate, or sulfate have been identified as members of the …

Resistance of solid tumors to treatment is significantly attributed to pharmacokinetic reasons
at both cellular and multi-cellular levels. Anticancer agent must be bio-available at the site of …