Heat shock factors (HSFs) are essential for all organisms to survive exposures to acute
stress. They are best known as inducible transcriptional regulators of genes encoding …

To dampen proteotoxic stresses and maintain protein homeostasis, organisms possess a
stress-responsive molecular machinery that detects and neutralizes protein damage. A …

The long-term health of the cell is inextricably linked to protein quality control. Under optimal
conditions this is accomplished by protein homeostasis, a highly complex network of …

The expression of heat shock proteins (Hsps) induced by nonlethal heat treatment confers
acquired thermotolerance (AT) to organisms against subsequent challenges of otherwise …

All organisms sense and respond to environmental and physiological stress by inducing cell
stress responses that protect core biosynthetic processes such as DNA repair, protein …

SUMO (small ubiquitin-like modifier) modification regulates many cellular processes,
including transcription. Although sumoylation often occurs on specific lysines within the …

Cataract is the leading cause of blindness among the elderly worldwide and cataract
surgery is one of the most common operations performed in the United States. As the …

Cataract can be defined as any opacity of the crystalline lens. Congenital cataract is
particularly serious because it has the potential for inhibiting visual development, resulting in …

Lens opacities, or cataract (s), may be inherited as a classic Mendelian disorder usually with
early-onset or, more commonly, acquired with age as a multi-factorial or complex trait. Many …

Living organisms are endowed with the capability to tackle various forms of cellular stress
due to the presence of molecular chaperone machinery complexes that are ubiquitous …