Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …

Despite the widespread clinical use of dynamic susceptibility contrast (DSC) MRI, DSC-MRI
methodology has not been standardized, hindering its utilization for response assessment in …

Advanced molecular and pathophysiologic characterization of primary central nervous
system lymphoma (PCNSL) has revealed insights into promising targeted therapeutic …

Background Glioblastoma (GBM) exhibits profound intratumoral genetic heterogeneity. Each
tumor comprises multiple genetically distinct clonal populations with different therapeutic …

Abstract High-grade glioma (HGG), and particularly Glioblastoma (GBM), can exhibit
pronounced intratumoral heterogeneity that confounds clinical diagnosis and management …

Objective Summarize evidence for use of advanced MRI techniques as monitoring
biomarkers in the clinic, and highlight the latest bench-to-bedside developments. Methods …

Sampling restrictions have hindered the comprehensive study of invasive non-enhancing
(NE) high-grade glioma (HGG) cell populations driving tumor progression. Here, we present …

Abstract INTRODUCTION: Contrast-enhanced MRI (CE-MRI) represents the current
mainstay for monitoring treatment response in glioblastoma multiforme (GBM), based on the …

Purpose To compare gadoteridol and ferumoxytol for measurement of relative cerebral
blood volume (rCBV) in patients with glioblastoma multiforme (GBM) who showed …

Background Genetic profiling represents the future of neuro-oncology but suffers from
inadequate biopsies in heterogeneous tumors like Glioblastoma (GBM). Contrast-enhanced …