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The angiotensin AT2 receptor: from a binding site to a novel therapeutic target
UM Steckelings, RE Widdop, ED Sturrock… - Pharmacological …, 2022 - Elsevier
Discovered more than 30 years ago, the angiotensin AT 2 receptor (AT 2 R) has evolved
from a binding site with unknown function to a firmly established major effector within the …
from a binding site with unknown function to a firmly established major effector within the …
Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer's disease: Past, present and future
F Gouveia, A Camins, M Ettcheto, J Bicker… - Ageing Research …, 2022 - Elsevier
Alzheimer's disease (AD) is a well-known neurodegenerative disease characterized by the
presence of two main hallmarks–Tau hyperphosphorylation and Aβ deposits …
presence of two main hallmarks–Tau hyperphosphorylation and Aβ deposits …
Modulation of angiotensin II signaling in the prevention of fibrosis
Over the last decade, it has become clear that the role of angiotensin II extends far beyond
recognized renal and cardiovascular effects. The presence of an autologous renin …
recognized renal and cardiovascular effects. The presence of an autologous renin …
Novel RAAS agonists and antagonists: clinical applications and controversies
CA Romero, M Orias, MR Weir - Nature Reviews Endocrinology, 2015 - nature.com
The renin–angiotensin–aldosterone system (RAAS) regulates blood pressure homeostasis
and vascular injury and repair responses. The RAAS was originally thought to be an …
and vascular injury and repair responses. The RAAS was originally thought to be an …
Targeting renin–angiotensin system against Alzheimer's disease
Renin Angiotensin System (RAS) is a hormonal system that regulates blood pressure and
fluid balance through a coordinated action of renal, cardiovascular, and central nervous …
fluid balance through a coordinated action of renal, cardiovascular, and central nervous …
Antihypertensive drugs and brain function: mechanisms underlying therapeutically beneficial and harmful neuropsychiatric effects
C Carnovale, C Perrotta, S Baldelli… - Cardiovascular …, 2023 - academic.oup.com
A bidirectional relationship exists between hypertension and psychiatric disorders, including
unipolar and bipolar depression, anxiety, post-traumatic stress disorder (PTSD), psychosis …
unipolar and bipolar depression, anxiety, post-traumatic stress disorder (PTSD), psychosis …
AT2 Receptor and Tissue Injury: Therapeutic Implications
P Namsolleck, C Recarti, S Foulquier… - Current hypertension …, 2014 - Springer
The renin-angiotensin system (RAS) plays an important role in the initiation and progression
of tissue injuries in the cardiovascular and nervous systems. The detrimental actions of the …
of tissue injuries in the cardiovascular and nervous systems. The detrimental actions of the …
Dopamine‐angiotensin interactions in the basal ganglia and their relevance for Parkinson's disease
JL Labandeira‐Garcia… - Movement …, 2013 - Wiley Online Library
Renin‐angiotensin systems are known to act in many tissues, for example, the blood vessel
wall or kidney, where a close interaction between angiotensin and dopamine has been …
wall or kidney, where a close interaction between angiotensin and dopamine has been …
The transcriptional landscape of dorsal root ganglia after sciatic nerve transection
S Li, C Xue, Y Yuan, R Zhang, Y Wang, Y Wang, B Yu… - Scientific reports, 2015 - nature.com
Following peripheral nerve injury, transcriptional responses are orchestrated to regulate the
expression of numerous genes in the lesioned nerve, thus activating the intrinsic …
expression of numerous genes in the lesioned nerve, thus activating the intrinsic …
Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis
E Bruce, V Shenoy, A Rathinasabapathy… - British Journal of …, 2015 - Wiley Online Library
Background and Purpose Pulmonary hypertension (PH) is a devastating disease
characterized by increased pulmonary arterial pressure, which progressively leads to right …
characterized by increased pulmonary arterial pressure, which progressively leads to right …