The 2015 ACMG/AMP sequence variant interpretation guideline provided a framework for
classifying variants based on several benign and pathogenic evidence criteria, including a …

Translational readthrough (TR) has come into renewed focus because systems biology
approaches have identified the first human genes undergoing functional translational …

Translation initiation is a major rate-limiting step for protein synthesis. However, recent
studies strongly suggest that the efficiency of protein synthesis is additionally regulated by …

The collection of chemically different protein variants, or proteoforms, by far exceeds the
number of protein-coding genes in the human genome. Major contributors are alternative …

So far, the annotation of translation initiation sites (TISs) has been based mostly upon
bioinformatics rather than experimental evidence. We adapted ribosomal footprinting to …

An approach combining fluorescence‐activated cell sorting and high‐throughput DNA
sequencing (FACS‐seq) was employed to determine the efficiency of start codon recognition …

N-terminal modifications play a major role in the fate of proteins in terms of activity, stability,
or subcellular compartmentalization. Such modifications remain poorly described and badly …

Usage of presumed 5′ UTR or downstream in-frame AUG codons, next to non-AUG codons
as translation start codons contributes to the diversity of a proteome as protein isoforms …

Thyroid hormone (TH) is essential for vertebrate development and the homeostasis of most
adult tissues, including bone. TH stimulates target gene expression through the nuclear …

Connexin 43 (Cx43, encoded by GJA1) is a cell-cell communication gap junction protein
expressed in all organ systems. It was recently found that GJA1 mRNA undergoes …