Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and
bioavailability of poorly water-soluble drugs. Various approaches have been employed to …

Hot-melt extrusion (HME) is a promising technology for the production of new chemical
entities in the developmental pipeline and for improving products already on the market. In …

Active pharmaceutical ingredients (APIs) may exist in various solid forms, which can lead to
differences in the intermolecular interactions, affecting the internal energy and enthalpy, and …

For administration of therapeutic agents, the oral route is favored since it is comfortable to
patients and also requires a reduced cost. Recently, a considerable amount of work has …

Spray drying is a well-established manufacturing technique which can be used to formulate
amorphous solid dispersions (ASDs) which is an effective strategy to deliver poorly water …

Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Co-amorphous drug delivery systems have recently gained considerable interest in the
pharmaceutical field because of their potential to improve oral bioavailability of poorly water …

Co-amorphous drug delivery systems (CAMS) are characterized by the combination of two
or more (initially crystalline) low molecular weight components that form a homogeneous …

Many approaches have been developed over time to overcome the bioavailability limitations
of poorly soluble drugs. With the advances in nanotechnology in recent decades, science …

Cellulose ethers have proven to be highly useful natural-based polymers, finding application
in areas including food, personal care products, oil field chemicals, construction, paper …