Matrix stiffness affects tumor-associated macrophage functional polarization and its potential in tumor therapy
J **ong, R **ao, J Zhao, Q Zhao, M Luo, F Li… - Journal of Translational …, 2024 - Springer
The extracellular matrix (ECM) plays critical roles in cytoskeletal support, biomechanical
transduction and biochemical signal transformation. Tumor-associated macrophage (TAM) …
transduction and biochemical signal transformation. Tumor-associated macrophage (TAM) …
Acute contact with profibrotic macrophages mechanically activates fibroblasts via αvβ3 integrin–mediated engagement of Piezo1
M Ezzo, K Spindler, JB Wang, D Lee, G Pecoraro… - Science …, 2024 - science.org
Fibrosis—excessive scarring after injury—causes> 40% of disease-related deaths
worldwide. In this misguided repair process, activated fibroblasts drive the destruction of …
worldwide. In this misguided repair process, activated fibroblasts drive the destruction of …
Biological and pharmacological roles of pyroptosis in pulmonary inflammation and fibrosis: recent advances and future directions
Y Liu, D Wang, X Liu, H Yuan, D Liu, Y Hu… - Cell Communication and …, 2024 - Springer
Pyroptosis, an inflammatory regulated cell death (RCD) mechanism, is characterized by
cellular swelling, membrane rupture, and subsequent discharge of cellular contents …
cellular swelling, membrane rupture, and subsequent discharge of cellular contents …
An immunomechanical checkpoint PYK2 governs monocyte-to-macrophage differentiation in pancreatic cancer
W **e, X Yu, Q Yang, N Ke, P Wang, H Kong, X Wu… - bioRxiv, 2024 - biorxiv.org
Pancreatic ductal adenocarcinoma (PDAC) is a highly fibrotic and stiff tumor, and tumor-
associated macrophages (TAMs) are pivotal in driving ECM remodeling, PDAC progression …
associated macrophages (TAMs) are pivotal in driving ECM remodeling, PDAC progression …