T-cell recognition of peptides incorporating nonsynonymous mutations, or neoepitopes, is a
cornerstone of tumor immunity and forms the basis of new immunotherapy approaches …

Understanding the structure–function relationship in proteins is a longstanding goal in
molecular and computational biology. The development of structure-based parameters has …

MHC restriction, which describes the binding of TCRs from CD4+ T cells to class II MHC
proteins and TCRs from CD8+ T cells to class I MHC proteins, is a hallmark of immunology …

Monoclonal antibodies are at the vanguard of the most promising cancer treatments.
Whereas traditional therapeutic antibodies have been limited to extracellular antigens, T cell …

How T-cell receptors (TCRs) can be intrinsically biased toward MHC proteins while
simultaneously display the structural adaptability required to engage diverse ligands …

Agonist binding to G-protein–coupled receptors (GPCRs) triggers signal transduction
cascades involving heterotrimeric G proteins as key players. A major obstacle for drug …

Inflammatory responses to hemin are believed to play an important role in tissue damage
and cerebral malaria pathology. Macrophage exposed to hemin exhibits modulation of non …

The identification of viral mutations that confer escape from antibodies is crucial for
understanding the interplay between immunity and viral evolution. We describe a molecular …

Polygalacturonases (PGs) are secreted by phytopathogenic fungi to degrade the plant cell
wall homogalacturonan during plant infection. To counteract Pgs, plants have evolved …

Pyruvate dehydrogenase complex deficiency is a major cause of primary lactic acidemia
resulting in high morbidity and mortality, with limited therapeutic options. PDHA1 mutations …