Plasmodium parasites experience significant bottlenecks as they transit through the
mosquito and are transmitted to their mammalian host. Oocyst prevalence on mosquito …

Plasmodium sporozoites exhibit a complex infection biology in the mosquito and
mammalian hosts. The sporozoite apical secretory organelles, the micronemes and …

In the malaria-causing parasite's life cycle, Plasmodium sporozoites must travel from the
midgut of a mosquito to the salivary glands before they can infect a mammalian host …

The malaria parasite has an extraordinary ability to evade the immune system due to which
the development of a malaria vaccine is a challenging task. Extensive research on malarial …

Malaria is caused by the unicellular parasite Plasmodium which is transmitted to humans
through the bite of infected female Anopheles mosquitoes. To initiate sexual reproduction …

Highlights•cAMP signalling is essential for invasion of red blood cells by malaria
parasites.•cAMP regulates phosphorylation of many essential merozoite proteins, including …

Plamepsin II has been identified as a therapeutic target in the Plasmodium falciparum's life
cycle and may lead to a drastic reduction in deaths caused by malaria worldwide. Africa flora …

Some parasitic diseases, such as malaria, require two hosts to complete their lifecycle: a
human and an insect vector. Although most malaria research has focused on parasite …

Background The invasion of the mosquito salivary glands by Plasmodium sporozoites is a
critical step that defines the success of malaria transmission and a detailed understanding of …

Background In spite of the global effort to eliminate malaria, it remains the most significant
vector-borne disease of humans. Plasmodium falciparum is the dominant malaria parasite in …