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[HTML][HTML] HRP2: transforming malaria diagnosis, but with caveats
The major growth in point-of-care malaria diagnosis over the past decade has been based
on immunochromatographic malaria rapid diagnostic tests (mRDTs), which generally detect …
on immunochromatographic malaria rapid diagnostic tests (mRDTs), which generally detect …
Genetic diversity and deletion of Plasmodium falciparum histidine-rich protein 2 and 3: a threat to diagnosis of P. falciparum malaria
Background PfHRP2-based rapid diagnostic tests (RDTs), based on the recognition of the
Plasmodium falciparum histidine-rich protein 2, are currently the most used tests in malaria …
Plasmodium falciparum histidine-rich protein 2, are currently the most used tests in malaria …
An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples
A Ahouidi, M Ali, J Almagro-Garcia… - Wellcome open …, 2021 - pmc.ncbi.nlm.nih.gov
MalariaGEN is a data-sharing network that enables groups around the world to work
together on the genomic epidemiology of malaria. Here we describe a new release of …
together on the genomic epidemiology of malaria. Here we describe a new release of …
Major threat to malaria control programs by Plasmodium falciparum lacking histidine-rich protein 2, Eritrea
A Berhane, K Anderson, S Mihreteab… - Emerging infectious …, 2018 - pmc.ncbi.nlm.nih.gov
False-negative results for Plasmodium falciparum histidine-rich protein (HRP) 2–based
rapid diagnostic tests (RDTs) are increasing in Eritrea. We investigated HRP gene 2/3 …
rapid diagnostic tests (RDTs) are increasing in Eritrea. We investigated HRP gene 2/3 …
High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion ty** by digital PCR to monitor malaria rapid diagnostic test efficacy
Most rapid diagnostic tests for Plasmodium falciparum malaria target the Histidine-Rich
Proteins 2 and 3 (HRP2 and HRP3). Deletions of the hrp2 and hrp3 genes result in false …
Proteins 2 and 3 (HRP2 and HRP3). Deletions of the hrp2 and hrp3 genes result in false …
Prevalence of pfhrp2 and/or pfhrp3 Gene Deletion in Plasmodium falciparum Population in Eight Highly Endemic States in India
Background Plasmodium falciparum encoded histidine rich protein (HRP2) based malaria
rapid diagnostic tests (RDTs) are used in India. Deletion of pfhrp2 and pfhrp3 genes …
rapid diagnostic tests (RDTs) are used in India. Deletion of pfhrp2 and pfhrp3 genes …
Independent Emergence of the Plasmodium falciparum Kelch Propeller Domain Mutant Allele C580Y in Guyana
Suspected artemisinin resistance in Plasmodium falciparum can be explored by examining
polymorphisms in the Kelch (PfK13) propeller domain. Sequencing of PfK13 and other gene …
polymorphisms in the Kelch (PfK13) propeller domain. Sequencing of PfK13 and other gene …
Plasmodium falciparum histidine rich protein-2 diversity and the implications for PfHRP 2: based malaria rapid diagnostic tests in Ghana
Background Malaria rapid diagnostic tests (RDTs) play a key role in malaria management
and control. The PfHRP-2 based RDT is the most widely used RDT for malaria diagnosis in …
and control. The PfHRP-2 based RDT is the most widely used RDT for malaria diagnosis in …
Plasmodium falciparum pfhrp2 and pfhrp3 gene deletions among patients enrolled at 100 health facilities throughout Tanzania: February to July 2021
Plasmodium falciparum with the histidine rich protein 2 gene (pfhrp2) deleted from its
genome can escape diagnosis by HRP2-based rapid diagnostic tests (HRP2-RDTs). The …
genome can escape diagnosis by HRP2-based rapid diagnostic tests (HRP2-RDTs). The …
Plasmodium falciparum pfhrp2 and pfhrp3 gene deletions and relatedness to other global isolates, Djibouti, 2019–2020
Deletions of pfhrp2 and paralogue pfhrp3 (pfhrp2/3) genes threaten Plasmodium falciparum
diagnosis by rapid diagnostic test. We examined 1,002 samples from suspected malaria …
diagnosis by rapid diagnostic test. We examined 1,002 samples from suspected malaria …