Application of modern and innovative spectroscopic and microscopic approaches to
biomedical analysis opens new horizons and sheds new light on many unexplored scientific …

Significance: Oxidative stress and generation of free radicals are fundamental in initiating
pathophysiological mechanisms leading to an inflammatory cascade resulting in high rates …

Background The increased procoagulant platelets and platelet activation are associated
with thrombosis in COVID-19. In this study, we investigated platelet activation in COVID-19 …

Pulmonary arterial hypertension (PAH) is a serious complication in β-thalassemia. The
mechanism of PAH development is believed to be through chronic platelet activation and …

Thromboembolic events including cerebral thrombosis, deep vein thrombosis, and
pulmonary embolism are major complications in β-thalassemia. Damaged red blood cells …

Introduction Platelets are main effector cells in haemostasis and also promote inflammation.
Platelet-leukocyte complexes are key mediators in a variety of thromboinflammatory …

HIGHLIGHTS•Extracellular vesicles cause a hypercoagulable state in patients with β-
thalassemia.•Extracellular vesicles can increase iron overload in patients with β …

A hypercoagulable state leading to a high risk of a thrombotic event is one of the most
common complications observed in β-thalassemia/HbE disease, particularly in patients who …

Background Patients with thalassaemia may have thromboembolic events and, even without
thrombosis, they have a subclinical hypercoagulable state. In this setting, several …

In the presence of red blood cells (RBCs), nitrite inhibits platelets through its conversion to
nitric oxide (NO) by the reductase activity of partially deoxygenated hemoglobin. Inhaled …