Caenorhabditis elegans as a Useful Model for Studying Aging Mutations

S Zhang, F Li, T Zhou, G Wang, Z Li - Frontiers in endocrinology, 2020 - frontiersin.org
The Caenorhabditis elegans genome possesses homologs of about two-thirds of all human
disease genes. Based on its physiological aging characteristics and superiority, the use of …

Network control principles predict neuron function in the Caenorhabditis elegans connectome

G Yan, PE Vértes, EK Towlson, YL Chew, DS Walker… - Nature, 2017 - nature.com
Recent studies on the controllability of complex systems offer a powerful mathematical
framework to systematically explore the structure–function relationship in biological, social …

Control principles for complex biological networks

M Li, H Gao, J Wang, FX Wu - Briefings in bioinformatics, 2019 - academic.oup.com
Networks have been widely used to model the structure of various biological systems.
Currently, a series of approaches have been developed to construct reliable biological …

Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic …

SN Baskoylu, J Yersak, P O'Hern, S Grosser… - PLoS …, 2018 - journals.plos.org
Mutations in Cu/Zn superoxide dismutase 1 (SOD1) lead to Amyotrophic Lateral Sclerosis
(ALS), a neurodegenerative disease that disproportionately affects glutamatergic and …

[HTML][HTML] A pathoconnectome of early neurodegeneration: Network changes in retinal degeneration

RL Pfeiffer, JR Anderson, J Dahal, JC Garcia… - Experimental eye …, 2020 - Elsevier
Connectomics has demonstrated that synaptic networks and their topologies are precise
and directly correlate with physiology and behavior. The next extension of connectomics is …

A C. elegans model for neurodegeneration in Cockayne syndrome

AFC Lopes, K Bozek, M Herholz… - Nucleic Acids …, 2020 - academic.oup.com
Cockayne syndrome (CS) is a congenital syndrome characterized by growth and mental
retardation, and premature ageing. The complexity of CS and mammalian models warrants …

A review of clustering methods in microorganism image analysis

C Li, F Kulwa, J Zhang, Z Li, H Xu, X Zhao - Information technology in …, 2021 - Springer
Clustering plays a great role in microorganism image segmentation, feature extraction and
classification, in all major application areas of microorganisms (medical, environmental …

Caenorhabditis elegans and the network control framework—FAQs

EK Towlson, PE Vértes, G Yan… - … of the Royal …, 2018 - royalsocietypublishing.org
Control is essential to the functioning of any neural system. Indeed, under healthy conditions
the brain must be able to continuously maintain a tight functional control between the …

A CNN framework based on line annotations for detecting nematodes in microscopic images

L Chen, M Strauch, M Daub, X Jiang… - 2020 IEEE 17th …, 2020 - ieeexplore.ieee.org
Plant parasitic nematodes cause damage to crop plants on a global scale. Robust detection
on image data is a prerequisite for monitoring such nematodes, as well as for many …

C22 disrupts embryogenesis and extends C. elegans lifespan

S Beydoun, A Sridhar, AM Tuckowski, E Wang… - Frontiers in …, 2023 - frontiersin.org
Caenorhabditis elegans is an instrumental model in aging research due to its large brood
size, short lifespan, and malleable genetics. However, maintaining a synchronous nematode …