Jasmonates act as signal transduction intermediates when plants are subjected to
environmental stresses such as UV radiation, osmotic shock and heat. In the past few years …

Inhibition of type 1 insulin-like growth factor receptor (IGF-1R) enhances tumor cell
sensitivity to ionizing radiation. It is not clear how this effect is mediated, nor whether this …

The microenvironment of the cancer cell is pivotal to its phenotypic regulation. One of the
central components of the microenvironment is temperature. An elevation in environmental …

Our previous studies demonstrate a differential expression of nitric oxide (NO) signaling
components in ES cells and our recent study demonstrated an enhanced differentiation of …

We have treated four prostate tumor cell lines, DU-145, PC-3, LNCaP and 22RV1 with
various concentrations of cisplatin in order to check for influence on viability and for onset of …

The cisplatin analogue 1R, 2R-diaminocyclohexane (trans-diacetato)(dichloro) platinum IV
(DAP) is a DNA-damaging agent that will be entering clinical trials for its potent cytotoxic …

Advanced prostate cancer cells are typically hormone independent, resistant to apoptosis
and do not respond to chemotherapeutic agents. The ability of methyl jasmonate (MJ) and …

Abstract cis-Diammine-dichloro-platinumII (cisplatin) is an inorganic, square-planar
coordination complex that has become one of the most important drugs in the clinical …

DNA damage activates cell cycle checkpoints and inhibits cell cycle progression. In G2
phase cells, the checkpoint response results in the inhibition of Cdc2/cyclin B activity, which …

The present invention is in the field of treatment of diseased tissues, including cancerous
tissues. In one embodiment, the present invention provides methods of identifying tissues …