Water-soluble conjugated polymers for imaging, diagnosis, and therapy

C Zhu, L Liu, Q Yang, F Lv, S Wang - Chemical reviews, 2012 - ACS Publications
Conjugated polymers (CPs) are characterized by a delocalized electronic structure that
exhibits efficient coupling between optoelectronic segments. Excitons can be efficiently …

Binding mode of Thioflavin T and other molecular probes in the context of amyloid fibrils—current status

M Groenning - Journal of chemical biology, 2010 - Springer
Because understanding amyloid fibrillation in molecular detail is essential for development
of strategies to control amyloid formation and overcome neurodegenerative disorders …

Prions: protein aggregation and infectious diseases

A Aguzzi, AM Calella - Physiological reviews, 2009 - journals.physiology.org
Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative
diseases that affect humans and a large variety of animals. The infectious agent responsible …

AA amyloidosis: pathogenesis and targeted therapy

GT Westermark, M Fändrich… - Annual Review of …, 2015 - annualreviews.org
The understanding of why and how proteins misfold and aggregate into amyloid fibrils has
increased considerably during recent years. Central to amyloid formation is an increase in …

Recent advances in conjugated polyelectrolytes for emerging optoelectronic applications

A Duarte, KY Pu, B Liu, GC Bazan - Chemistry of Materials, 2011 - ACS Publications
This review summarizes recent advances in the science and applications of conjugated
polyelectrolytes (CPEs), with an emphasis on direct visual sensing, cellular imaging, and the …

Novel Pentameric Thiophene Derivatives for in Vitro and in Vivo Optical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses

A Åslund, CJ Sigurdson, T Klingstedt… - ACS chemical …, 2009 - ACS Publications
Molecular probes for selective identification of protein aggregates are important to advance
our understanding of the molecular pathogenesis underlying cerebral amyloidoses. Here we …

Optical detection of DNA and proteins with cationic polythiophenes

HA Ho, A Najari, M Leclerc - Accounts of chemical research, 2008 - ACS Publications
In recent years, intense research has been carried out worldwide with the goal of develo**
simple, sensitive, and specific detection tools for biomedical applications. Along these lines …

Systemic amyloidoses

LM Blancas-Mejía… - Annual review of …, 2013 - annualreviews.org
The amyloidoses are a group of protein misfolding diseases in which the precursor protein
undergoes a conformational change that triggers the formation of amyloid fibrils in different …

Amyloid fibril polymorphism: a challenge for molecular imaging and therapy

M Fändrich, S Nyström, KPR Nilsson… - Journal of Internal …, 2018 - Wiley Online Library
The accumulation of misfolded proteins (MP s), both unique and common, for different
diseases is central for many chronic degenerative diseases. In certain patients, MP …

Imaging of β-amyloid plaques by near infrared fluorescent tracers: a new frontier for chemical neuroscience

M Staderini, MA Martín, ML Bolognesi… - Chemical Society …, 2015 - pubs.rsc.org
Brain amyloid depositions are the main hallmarks of Alzheimer's and other protein
misfolding diseases. Since they are believed to precede clinical symptoms by several years …