Water-soluble conjugated polymers for imaging, diagnosis, and therapy
Conjugated polymers (CPs) are characterized by a delocalized electronic structure that
exhibits efficient coupling between optoelectronic segments. Excitons can be efficiently …
exhibits efficient coupling between optoelectronic segments. Excitons can be efficiently …
Binding mode of Thioflavin T and other molecular probes in the context of amyloid fibrils—current status
M Groenning - Journal of chemical biology, 2010 - Springer
Because understanding amyloid fibrillation in molecular detail is essential for development
of strategies to control amyloid formation and overcome neurodegenerative disorders …
of strategies to control amyloid formation and overcome neurodegenerative disorders …
Prions: protein aggregation and infectious diseases
A Aguzzi, AM Calella - Physiological reviews, 2009 - journals.physiology.org
Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative
diseases that affect humans and a large variety of animals. The infectious agent responsible …
diseases that affect humans and a large variety of animals. The infectious agent responsible …
AA amyloidosis: pathogenesis and targeted therapy
GT Westermark, M Fändrich… - Annual Review of …, 2015 - annualreviews.org
The understanding of why and how proteins misfold and aggregate into amyloid fibrils has
increased considerably during recent years. Central to amyloid formation is an increase in …
increased considerably during recent years. Central to amyloid formation is an increase in …
Recent advances in conjugated polyelectrolytes for emerging optoelectronic applications
This review summarizes recent advances in the science and applications of conjugated
polyelectrolytes (CPEs), with an emphasis on direct visual sensing, cellular imaging, and the …
polyelectrolytes (CPEs), with an emphasis on direct visual sensing, cellular imaging, and the …
Novel Pentameric Thiophene Derivatives for in Vitro and in Vivo Optical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses
Molecular probes for selective identification of protein aggregates are important to advance
our understanding of the molecular pathogenesis underlying cerebral amyloidoses. Here we …
our understanding of the molecular pathogenesis underlying cerebral amyloidoses. Here we …
Optical detection of DNA and proteins with cationic polythiophenes
HA Ho, A Najari, M Leclerc - Accounts of chemical research, 2008 - ACS Publications
In recent years, intense research has been carried out worldwide with the goal of develo**
simple, sensitive, and specific detection tools for biomedical applications. Along these lines …
simple, sensitive, and specific detection tools for biomedical applications. Along these lines …
Systemic amyloidoses
LM Blancas-Mejía… - Annual review of …, 2013 - annualreviews.org
The amyloidoses are a group of protein misfolding diseases in which the precursor protein
undergoes a conformational change that triggers the formation of amyloid fibrils in different …
undergoes a conformational change that triggers the formation of amyloid fibrils in different …
Amyloid fibril polymorphism: a challenge for molecular imaging and therapy
M Fändrich, S Nyström, KPR Nilsson… - Journal of Internal …, 2018 - Wiley Online Library
The accumulation of misfolded proteins (MP s), both unique and common, for different
diseases is central for many chronic degenerative diseases. In certain patients, MP …
diseases is central for many chronic degenerative diseases. In certain patients, MP …
Imaging of β-amyloid plaques by near infrared fluorescent tracers: a new frontier for chemical neuroscience
Brain amyloid depositions are the main hallmarks of Alzheimer's and other protein
misfolding diseases. Since they are believed to precede clinical symptoms by several years …
misfolding diseases. Since they are believed to precede clinical symptoms by several years …