[HTML][HTML] Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review

CL Wainwright, MM Teixeira, DL Adelson… - Pharmacological …, 2022 - Elsevier
Drug discovery from natural sources is going through a renaissance, having spent many
decades in the shadow of synthetic molecule drug discovery, despite the fact that natural …

[HTML][HTML] Antimicrobial lipids from plants and marine organisms: An overview of the current state-of-the-art and future prospects

E Alves, M Dias, D Lopes, A Almeida, MR Domingues… - Antibiotics, 2020 - mdpi.com
In the actual post-antibiotic era, novel ways of rethinking antimicrobial research approaches
are more urgent than ever. Natural compounds with antimicrobial activity such as fatty acids …

[HTML][HTML] Bioassay guided fractionation protocol for determining novel active compounds in selected Australian flora

J Mani, J Johnson, H Hosking, BE Hoyos, KB Walsh… - Plants, 2022 - mdpi.com
A large variety of unique and distinct flora of Australia have developed exceptional survival
methods and phytochemicals and hence may provide a significant avenue for new drug …

Evaluation of the anti-inflammatory and antioxidant properties and isolation and characterization of a new bioactive compound, 3, 4, 9-trimethyl-7-propyldecanoic acid …

S Sivapalan, S Dharmalingam, V Ashokkumar… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Herbal medicines derived from plant extraction are
affordable, more therapeutically effective, and have fewer side effects than contemporary …

Designed genotoxicity profiling detects genotoxic compounds in staple food such as healthy oils

GE Morlock, D Meyer - Food Chemistry, 2023 - Elsevier
Current techniques used in food analysis overlook genotoxic compounds. This urgently calls
for a paradigm shift in analytics towards non-target planar genotoxicity profiling that can …

Current and emerging tools and strategies for the identification of bioactive natural products in complex mixtures

M Meunier, A Schinkovitz, S Derbré - Natural Product Reports, 2024 - pubs.rsc.org
Covering: up to 2024The prompt identification of (bio) active natural products (NPs) from
complex mixtures poses a significant challenge due to the presence of numerous …

[HTML][HTML] Scorpion venom as a source of antimicrobial peptides: overview of biomolecule separation, analysis and characterization methods

S Nasr, A Borges, C Sahyoun, R Nasr, R Roufayel… - Antibiotics, 2023 - mdpi.com
Scorpion venoms have long captivated scientific researchers, primarily due to the potency
and specificity of the mechanism of action of their derived components. Among other …

[HTML][HTML] The Dawn till Dusk of phytopharmaceuticals

R Tiwari, S Mishra, A Chauhan, P Gulati… - Saudi Pharmaceutical …, 2024 - Elsevier
Herbal products and their formulations have a large market at the global level. A significant
portion of the worldwide population relies upon herbal treatment. Their apparent non-toxic …

Looking for Actives in the Haystack: Merging HRMS2-Based Molecular Networking, Chemometrics, and 13C NMR-Based Dereplication Approaches

M Meunier, D Bréard, S Boisard… - Journal of Natural …, 2024 - ACS Publications
The identification of bioactive natural products (NPs) in complex mixtures has become an
important subject of contemporary NP research. In an attempt to address this challenge, the …