Precision diagnostics: moving towards protein biomarker signatures of clinical utility in cancer

CAK Borrebaeck - Nature Reviews Cancer, 2017 - nature.com
Interest in precision diagnostics has been fuelled by the concept that early detection of
cancer would benefit patients; that is, if detected early, more tumours should be resectable …

Multifactorial scores and biomarkers of prognosis of acute pancreatitis: applications to research and practice

P Silva-Vaz, AM Abrantes, M Castelo-Branco… - International journal of …, 2020 - mdpi.com
Acute pancreatitis (AP) is a severe inflammation of the pancreas presented with sudden
onset and severe abdominal pain with a high morbidity and mortality rate, if accompanied by …

Serum biomarker signature-based liquid biopsy for diagnosis of early-stage pancreatic cancer

LD Mellby, AP Nyberg, JS Johansen… - Journal of Clinical …, 2018 - ascopubs.org
Purpose Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, with a 5-year
survival of< 10% because of diffuse symptoms leading to late-stage diagnosis. That survival …

Protein microarray technology: how far off is routine diagnostics?

M Cretich, F Damin, M Chiari - Analyst, 2014 - pubs.rsc.org
The nature of protein microarray platforms is favorable for multiplexing, leading to the
development of tools for personalised medicine and highly precise diagnostics. However, to …

Biomarkers of chronic pancreatitis: a systematic literature review

Z Cruz-Monserrate, K Gumpper, V Pita, PA Hart… - Pancreatology, 2021 - Elsevier
Background Chronic pancreatitis (CP) does not have diagnostic or prognostic biomarkers.
CP is the end stage of a progressive inflammatory syndrome that is diagnosed at late stages …

[HTML][HTML] Differential miRNA and protein expression reveals miR-1285, its targets TGM2 and CDH-1, as well as CD166 and S100A13 as potential new biomarkers in …

T Kolokotronis, B Majchrzak-Stiller, M Buchholz… - Cancers, 2024 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma is a very lethal tumor entity with the late
appearance of clinical signs and the absence of biomarkers for early diagnosis. Diabetes …

Proteomic and metaproteomic approaches to understand host–microbe interactions

AE Starr, SA Deeke, L Li, X Zhang, R Daoud… - Analytical …, 2018 - ACS Publications
The human body is composed not only of human cells but is occupied by bacteria, archaea,
fungi, and viruses; this ensemble of organisms (microbiota) and their expressed genes are …

A cost-effective high-throughput plasma and serum proteomics workflow enables map** of the molecular impact of total pancreatectomy with islet …

TB Bennike, MD Bellin, Y Xuan… - Journal of proteome …, 2018 - ACS Publications
Blood is an ideal body fluid for the discovery or monitoring of diagnostic and prognostic
protein biomarkers. However, discovering robust biomarkers requires the analysis of large …

The role of proteomics in acute pancreatitis: new and old knowledge

P Ge, Y Luo, G Zhang, H Chen - Expert Review of Proteomics, 2024 - Taylor & Francis
Introduction Around 20% of individuals diagnosed with acute pancreatitis (AP) may develop
severe acute pancreatitis (SAP), possibly resulting in a mortality rate ranging from 15% to …

Immunocapture strategies in translational proteomics

C Fredolini, S Byström, E Pin, F Edfors… - Expert review of …, 2016 - Taylor & Francis
Aiming at clinical studies of human diseases, antibody-assisted assays have been applied
to biomarker discovery and toward a streamlined translation from patient profiling to assays …