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Antimicrobial peptides: diversity, mechanism of action and strategies to improve the activity and biocompatibility in vivo
Antibiotic resistance is projected as one of the greatest threats to human health in the future
and hence alternatives are being explored to combat resistance. Antimicrobial peptides …
and hence alternatives are being explored to combat resistance. Antimicrobial peptides …
[HTML][HTML] Mechanisms and consequences of bacterial resistance to antimicrobial peptides
Cationic antimicrobial peptides (AMPs) are an intrinsic part of the human innate immune
system. Over 100 different human AMPs are known to exhibit broad-spectrum antibacterial …
system. Over 100 different human AMPs are known to exhibit broad-spectrum antibacterial …
Defensins: The natural peptide antibiotic
Defensins are a family of cationic antimicrobial peptides active against a broad range of
infectious microbes including bacteria, viruses and fungi, playing important roles as innate …
infectious microbes including bacteria, viruses and fungi, playing important roles as innate …
Mechanistic landscape of membrane-permeabilizing peptides
Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …
Immunomodulatory and allergenic properties of antimicrobial peptides
With the growing problem of the emergence of antibiotic-resistant bacteria, the search for
alternative ways to combat bacterial infections is extremely urgent. While analyzing the effect …
alternative ways to combat bacterial infections is extremely urgent. While analyzing the effect …
Designing of multi-epitope peptide vaccine against Acinetobacter baumannii through combined immunoinformatics and protein interaction–based approaches
Acinetobacter baumannii is one of the major pathogenic ESKAPE bacterium, which is
responsible for about more than 722,000 cases in a year, globally. Despite the alarming …
responsible for about more than 722,000 cases in a year, globally. Despite the alarming …
Melanocortin 1 receptor: structure, function, and regulation
EM Wolf Horrell, MC Boulanger, JA D'Orazio - Frontiers in genetics, 2016 - frontiersin.org
The melanocortin 1 receptor (MC1R) is a melanocytic Gs protein coupled receptor that
regulates skin pigmentation, UV responses, and melanoma risk. It is a highly polymorphic …
regulates skin pigmentation, UV responses, and melanoma risk. It is a highly polymorphic …
The roles of antimicrobial peptides in innate host defense
Antimicrobial peptides (AMPs) are multi-functional peptides whose fundamental biological
role in vivo has been proposed to be the elimination of pathogenic microorganisms …
role in vivo has been proposed to be the elimination of pathogenic microorganisms …
Mammalian defensins in the antimicrobial immune response
ME Selsted, AJ Ouellette - Nature immunology, 2005 - nature.com
Defensins are peptidic components of the innate immune system of plants and animals. In
mammals, defensins have evolved to have a central function in the host defense properties …
mammals, defensins have evolved to have a central function in the host defense properties …
Human antimicrobial peptides and proteins
G Wang - Pharmaceuticals, 2014 - mdpi.com
As the key components of innate immunity, human host defense antimicrobial peptides and
proteins (AMPs) play a critical role in warding off invading microbial pathogens. In addition …
proteins (AMPs) play a critical role in warding off invading microbial pathogens. In addition …