Antimicrobial peptides: diversity, mechanism of action and strategies to improve the activity and biocompatibility in vivo

P Kumar, JN Kizhakkedathu, SK Straus - Biomolecules, 2018 - mdpi.com
Antibiotic resistance is projected as one of the greatest threats to human health in the future
and hence alternatives are being explored to combat resistance. Antimicrobial peptides …

[HTML][HTML] Mechanisms and consequences of bacterial resistance to antimicrobial peptides

DI Andersson, D Hughes… - Drug Resistance Updates, 2016 - Elsevier
Cationic antimicrobial peptides (AMPs) are an intrinsic part of the human innate immune
system. Over 100 different human AMPs are known to exhibit broad-spectrum antibacterial …

Defensins: The natural peptide antibiotic

X Gao, J Ding, C Liao, J Xu, X Liu, W Lu - Advanced drug delivery reviews, 2021 - Elsevier
Defensins are a family of cationic antimicrobial peptides active against a broad range of
infectious microbes including bacteria, viruses and fungi, playing important roles as innate …

Mechanistic landscape of membrane-permeabilizing peptides

S Guha, J Ghimire, E Wu, WC Wimley - Chemical reviews, 2019 - ACS Publications
Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …

Immunomodulatory and allergenic properties of antimicrobial peptides

SV Guryanova, TV Ovchinnikova - International journal of molecular …, 2022 - mdpi.com
With the growing problem of the emergence of antibiotic-resistant bacteria, the search for
alternative ways to combat bacterial infections is extremely urgent. While analyzing the effect …

Designing of multi-epitope peptide vaccine against Acinetobacter baumannii through combined immunoinformatics and protein interaction–based approaches

J Dey, SR Mahapatra, PK Singh… - Immunologic …, 2023 - Springer
Acinetobacter baumannii is one of the major pathogenic ESKAPE bacterium, which is
responsible for about more than 722,000 cases in a year, globally. Despite the alarming …

Melanocortin 1 receptor: structure, function, and regulation

EM Wolf Horrell, MC Boulanger, JA D'Orazio - Frontiers in genetics, 2016 - frontiersin.org
The melanocortin 1 receptor (MC1R) is a melanocytic Gs protein coupled receptor that
regulates skin pigmentation, UV responses, and melanoma risk. It is a highly polymorphic …

The roles of antimicrobial peptides in innate host defense

G Diamond, N Beckloff, A Weinberg… - Current …, 2009 - ingentaconnect.com
Antimicrobial peptides (AMPs) are multi-functional peptides whose fundamental biological
role in vivo has been proposed to be the elimination of pathogenic microorganisms …

Mammalian defensins in the antimicrobial immune response

ME Selsted, AJ Ouellette - Nature immunology, 2005 - nature.com
Defensins are peptidic components of the innate immune system of plants and animals. In
mammals, defensins have evolved to have a central function in the host defense properties …

Human antimicrobial peptides and proteins

G Wang - Pharmaceuticals, 2014 - mdpi.com
As the key components of innate immunity, human host defense antimicrobial peptides and
proteins (AMPs) play a critical role in warding off invading microbial pathogens. In addition …