Glutamate is the most abundant free amino acid in the brain and is at the crossroad between
multiple metabolic pathways. Considering this, it was a surprise to discover that glutamate …

Parkinson's disease (PD) is a common neurodegenerative disease, the pathological
features of which include the presence of Lewy bodies and the neurodegeneration of …

Astrocytes have in recent years become the focus of intense experimental interest, yet
markers for their definitive identification remain both scarce and imperfect. Astrocytes may …

Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …

GLT-1 (EAAT2; slc1a2) is the major glutamate transporter in the brain, and is predominantly
expressed in astrocytes, but at lower levels also in excitatory terminals. We generated a …

The mammalian genome contains four genes encoding GABA transporters (GAT1, slc6a1;
GAT2, slc6a13; GAT3, slc6a11; BGT1, slc6a12) and five glutamate transporter genes …

Recent work on glial cell physiology has revealed that glial cells, and astrocytes in
particular, are much more actively involved in brain information processing than previously …

Neither normal brain function nor the pathological processes involved in neurological
diseases can be adequately understood without knowledge of the release, uptake and …

Extracellular concentrations of the predominant excitatory neurotransmitter, glutamate, and
related excitatory amino acids are maintained at relatively low levels to ensure an …

Astrocytes, the major glial cell type in the central nervous system (CNS), are critical for brain
function and have been implicated in various disorders of the central nervous system. These …