Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Poly (ethylene glycol) alternatives in biomedical applications

X Yao, C Qi, C Sun, F Huo, X Jiang - Nano Today, 2023 - Elsevier
Abstract Poly (ethylene glycol)(PEG) as gold standard has been extensively conjugated to
diagnostic and therapeutic agents or decorated on the surface of nanoplatforms, which is …

Star polymers

JM Ren, TG McKenzie, Q Fu, EHH Wong, J Xu… - Chemical …, 2016 - ACS Publications
Recent advances in controlled/living polymerization techniques and highly efficient coupling
chemistries have enabled the facile synthesis of complex polymer architectures with …

[HTML][HTML] Copper-mediated living radical polymerization (atom transfer radical polymerization and copper (0) mediated polymerization): from fundamentals to …

C Boyer, NA Corrigan, K Jung, D Nguyen… - Chemical …, 2016 - ACS Publications
The discovery of the first “living” radical polymerization by Otsu and co-workers (1) in 1982
heralded the start of a very exciting time for polymer chemists. Since then, a plethora of living …

Co-delivery of drugs and plasmid DNA for cancer therapy

PY Teo, W Cheng, JL Hedrick, YY Yang - Advanced drug delivery reviews, 2016 - Elsevier
Cancer is an extremely complex disease involving multiple signaling pathways that enable
tumor cells to evade programmed cell death, thus making cancer treatment extremely …

Harnessing amphiphilic polymeric micelles for diagnostic and therapeutic applications: Breakthroughs and bottlenecks

J Kaur, V Mishra, SK Singh, M Gulati, B Kapoor… - Journal of Controlled …, 2021 - Elsevier
Amphiphilic block copolymers are widely utilized in the design of formulations owing to their
unique physicochemical properties, flexible structures and functional chemistry. Amphiphilic …

Recent progress in nanomaterials for gene delivery applications

E Keles, Y Song, D Du, WJ Dong, Y Lin - Biomaterials science, 2016 - pubs.rsc.org
Nanotechnology-based gene delivery is the division of nanomedicine concerned with the
synthesis, characterization, and functionalization of nanomaterials to be used in targeted …

A facile-synthesized star polycation constructed as a highly efficient gene vector in pest management

J Li, J Qian, Y Xu, S Yan, J Shen… - … Sustainable Chemistry & …, 2019 - ACS Publications
Gene vectors have been extensively applied in various fields. However, the high economic
cost of gene vectors limits their development and application, and there is an urgent demand …

Recent advances of zwitterionic-based topological polymers for biomedical applications

M Zhang, P Yu, J **e, J Li - Journal of Materials Chemistry B, 2022 - pubs.rsc.org
Zwitterionic polymers, comprising hydrophilic anionic and cationic groups with the same
total number of positive and negative charges on the same monomer residue, have received …

Redox‐responsive and drug‐embedded silica nanoparticles with unique self‐destruction features for efficient gene/drug codelivery

Q Zhang, C Shen, N Zhao, FJ Xu - Advanced Functional …, 2017 - Wiley Online Library
The development of advanced gene/drug codelivery carriers with stimuli‐responsive release
manner for complementary cancer therapy is desirable. In this study, novel disulfide‐bridged …