Fighting age-related orthopedic diseases: focusing on ferroptosis

Q Ru, Y Li, W **e, Y Ding, L Chen, G Xu, Y Wu… - Bone research, 2023 - nature.com
Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation
and lipid peroxidation. It is closely related to multiple biological processes, including iron …

[HTML][HTML] Cell death regulation: a new way for natural products to treat osteoporosis

Z Li, D Li, R Chen, S Gao, Z Xu, N Li - Pharmacological research, 2023 - Elsevier
Osteoporosis is a common metabolic bone disease that results from the imbalance of
homeostasis within the bone. Intra-bone homeostasis is dependent on a precise dynamic …

A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis

Y Li, Z Cai, W Ma, L Bai, E Luo, Y Lin - Bone Research, 2024 - nature.com
Diabetic osteoporosis (DOP) is a significant complication that poses continuous threat to the
bone health of patients with diabetes; however, currently, there are no effective treatment …

Secondary osteoporosis

PR Ebeling, HH Nguyen, J Aleksova… - Endocrine …, 2022 - academic.oup.com
Osteoporosis is a global public health problem, with fractures contributing to significant
morbidity and mortality. Although postmenopausal osteoporosis is most common, up to 30 …

Molecular mechanisms and emerging therapeutics for osteoporosis

JY Noh, Y Yang, H Jung - International journal of molecular sciences, 2020 - mdpi.com
Osteoporosis is the most common chronic metabolic bone disease. It has been estimated
that more than 10 million people in the United States and 200 million men and women …

Ferroptosis: a new regulatory mechanism in osteoporosis

P Liu, W Wang, Z Li, Y Li, X Yu, J Tu… - Oxidative Medicine and …, 2022 - Wiley Online Library
Osteoporosis can be caused by a multitude of factors and is defined by a decrease in bone
density and mass caused by the destruction of bone microstructure, resulting in increased …

Iron overload‐induced ferroptosis of osteoblasts inhibits osteogenesis and promotes osteoporosis: An in vitro and in vivo study

Z Jiang, H Wang, G Qi, C Jiang, K Chen, Z Yan - IUBMB life, 2022 - Wiley Online Library
Growing evidence indicates that iron overload is an independent risk factor for osteoporosis.
However, the mechanisms are not fully understood. The purpose of our study was to …

A review of metal exposure and its effects on bone health

J Rodríguez, PM Mandalunis - Journal of toxicology, 2018 - Wiley Online Library
The presence of metals in the environment is a matter of concern, since human activities are
the major cause of pollution and metals can enter the food chain and bioaccumulate in hard …

Canonical Wnt signaling works downstream of iron overload to prevent ferroptosis from damaging osteoblast differentiation

C Luo, W Xu, X Tang, X Liu, Y Cheng, Y Wu… - Free Radical Biology …, 2022 - Elsevier
Excessive iron has emerged in a large population of patients suffering from degenerative or
hematological diseases with a common outcome, osteoporosis. However, its underlying …

Applications of metals for bone regeneration

K Glenske, P Donkiewicz, A Köwitsch… - International journal of …, 2018 - mdpi.com
The regeneration of bone tissue is the main purpose of most therapies in dental medicine.
For bone regeneration, calcium phosphate (CaP)-based substitute materials based on …