The translational landscape in spinal cord injury: focus on neuroplasticity and regeneration

TH Hutson, S Di Giovanni - Nature Reviews Neurology, 2019 - nature.com
Over the past decade, we have witnessed a flourishing of novel strategies to enhance
neuroplasticity and promote axon regeneration following spinal cord injury, and results from …

Restoring sensorimotor function through intracortical interfaces: progress and looming challenges

SJ Bensmaia, LE Miller - Nature Reviews Neuroscience, 2014 - nature.com
The loss of a limb or paralysis resulting from spinal cord injury has devastating
consequences on quality of life. One approach to restoring lost sensory and motor abilities in …

Intracortical microstimulation of human somatosensory cortex

SN Flesher, JL Collinger, ST Foldes… - Science translational …, 2016 - science.org
Intracortical microstimulation of the somatosensory cortex offers the potential for creating a
sensory neuroprosthesis to restore tactile sensation. Whereas animal studies have …

Neuromodulation in the restoration of function after spinal cord injury

ND James, SB McMahon, EC Field-Fote… - The Lancet …, 2018 - thelancet.com
Neuromodulation, the use of electrical interfaces to alter neuronal activity, has been
successful as a treatment approach in several neurological disorders, including deep brain …

[HTML][HTML] DARPA-funded efforts in the development of novel brain–computer interface technologies

RA Miranda, WD Casebeer, AM Hein, JW Judy… - Journal of neuroscience …, 2015 - Elsevier
Abstract The Defense Advanced Research Projects Agency (DARPA) has funded innovative
scientific research and technology developments in the field of brain–computer interfaces …

Multifaceted understanding of human nerve implants to design optimized electrodes for bioelectronics

G Valle, G Aiello, F Ciotti, P Cvancara, T Martinovic… - Biomaterials, 2022 - Elsevier
Bioelectronic medicine is a promising venue for treatment of disabilities using implantable
neural interfaces. Peripheral neurostimulation of residual nerves recently enabled multiple …

Explant analysis of Utah electrode arrays implanted in human cortex for brain-computer-interfaces

K Woeppel, C Hughes, AJ Herrera, JR Eles… - … in Bioengineering and …, 2021 - frontiersin.org
Brain-computer interfaces are being developed to restore movement for people living with
paralysis due to injury or disease. Although the therapeutic potential is great, long-term …

Intracortical somatosensory stimulation to elicit fingertip sensations in an individual with spinal cord injury

MS Fifer, DP McMullen, LE Osborn, TM Thomas… - Neurology, 2022 - AAN Enterprises
Background and Objectives The restoration of touch to fingers and fingertips is critical to
achieving dexterous neuroprosthetic control for individuals with sensorimotor dysfunction …

Electrode materials for chronic electrical microstimulation

XS Zheng, C Tan, E Castagnola… - Advanced healthcare …, 2021 - Wiley Online Library
Electrical microstimulation has enabled partial restoration of vision, hearing, movement,
somatosensation, as well as improving organ functions by electrically modulating neural …

Behavioral assessment of sensitivity to intracortical microstimulation of primate somatosensory cortex

S Kim, T Callier, GA Tabot, RA Gaunt… - Proceedings of the …, 2015 - National Acad Sciences
Intracortical microstimulation (ICMS) is a powerful tool to investigate the functional role of
neural circuits and may provide a means to restore sensation for patients for whom …