Isoprenoid biosynthesis in bacterial pathogens
Isoprenoid biosynthesis is essential for cell survival. Over 35 000 isoprenoid molecules have
been identified to date in the three domains of life (bacteria, archaea and eukaryotes), and …
been identified to date in the three domains of life (bacteria, archaea and eukaryotes), and …
[HTML][HTML] Bioactive substances of cyanobacteria and microalgae: sources, metabolism, and anticancer mechanism insights
Cyanobacteria and microalgae contain various phytochemicals, including bioactive
components in the form of secondary metabolites, namely flavonoids, phenolic acids …
components in the form of secondary metabolites, namely flavonoids, phenolic acids …
Genome-based identification and comparative analysis of enzymes for carotenoid biosynthesis in microalgae
Microalgae are potential feedstocks for the commercial production of carotenoids, however,
the metabolic pathways for carotenoid biosynthesis across algal lineage are largely …
the metabolic pathways for carotenoid biosynthesis across algal lineage are largely …
Drugs and their molecular targets: an updated overview
Y Landry, JP Gies - Fundamental & clinical pharmacology, 2008 - Wiley Online Library
About 330 targets bind approved drugs, 270 encoded by the human genome and 60
belonging to pathogenic organisms. A large number of druggable targets have been …
belonging to pathogenic organisms. A large number of druggable targets have been …
Over 40 years of fosmidomycin drug research: a comprehensive review and future opportunities
T Knak, MA Abdullaziz, S Höfmann, LA Alves Avelar… - Pharmaceuticals, 2022 - mdpi.com
To address the continued rise of multi-drug-resistant microorganisms, the development of
novel drugs with new modes of action is urgently required. While humans biosynthesize the …
novel drugs with new modes of action is urgently required. While humans biosynthesize the …
Metabolic pathways in the apicoplast of apicomplexa
F Seeber, D Soldati-Favre - International review of cell and molecular …, 2010 - Elsevier
Intracellular parasites of the phylum Apicomplexa harbor a plastid-like organelle called
apicoplast that is the most reduced organelle of this type known. Due to the medical …
apicoplast that is the most reduced organelle of this type known. Due to the medical …
Biosynthesis of carotenoids in plants: enzymes and color
C Rosas-Saavedra, C Stange - Carotenoids in nature: biosynthesis …, 2016 - Springer
Carotenoids are the most important biocolor isoprenoids responsible for yellow, orange and
red colors found in nature. In plants, they are synthesized in plastids of photosynthetic and …
red colors found in nature. In plants, they are synthesized in plastids of photosynthetic and …
Novel antibacterials: alternatives to traditional antibiotics
With the advent of the global antimicrobial resistance (AMR) crisis, our arsenal of effective
antibiotics is diminishing. The widespread use and misuse of antibiotics in human and …
antibiotics is diminishing. The widespread use and misuse of antibiotics in human and …
Identifying essential genes in bacterial metabolic networks with machine learning methods
Background Identifying essential genes in bacteria supports to identify potential drug targets
and an understanding of minimal requirements for a synthetic cell. However, experimentally …
and an understanding of minimal requirements for a synthetic cell. However, experimentally …
Molecular basis of fosmidomycin's action on the human malaria parasite Plasmodium falciparum
T Umeda, N Tanaka, Y Kusakabe, M Nakanishi… - Scientific Reports, 2011 - nature.com
The human malaria parasite Plasmodium falciparum is responsible for the deaths of more
than a million people each year. Fosmidomycin has been proven to be efficient in the …
than a million people each year. Fosmidomycin has been proven to be efficient in the …