Cancer is a leading cause of death in many countries around the world. However, the
efficacy of current standard treatments for a variety of cancers is suboptimal. First, most …

Personalised and targeted interventions have revolutionised cancer treatment and
dramatically improved survival rates in recent decades. Nonetheless, effective pain …

Neurotoxic side effects of cancer therapy are second in frequency to hematological toxicity.
Unlike hematological side effects that can be treated with hematopoietic growth factors …

This article reviews the investigations undertaken into platinum (IV) antitumour compounds
since Barnett Rosenberg first noted the activity of platinum (IV) complexes. The chemical …

Cancer pain significantly affects the diagnosis, quality of life and survival of patients with
cancer. During the past decade, preclinical and clinical data has begun to provide insight …

Peripheral neuropathy induced by cancer chemotherapy represents a large unmet need for
patients due to the absence of treatment that can prevent or mitigate this common clinical …

Sucralose is a synthetic organochlorine sweetener (OC) that is a common ingredient in the
world's food supply. Sucralose interacts with chemosensors in the alimentary tract that play a …

Thirty years after the onset of the first clinical studies with cisplatin, the development of
antineoplastic platinum drugs continues to be a productive field of research. This article …

In spite of the clinical usefulness of cisplatin (CDDP), there are many occasions in which it is
difficult to continue the administration of CDDP due to its nephrotoxicity and neurotoxicity …

Cisplatin has been in use for 40 years, primarily for treatment of ovarian and testicular
cancer. Oxaliplatin is the only effective treatment for metastatic colorectal cancer …