Mental illness modeling is still a major challenge for scientists. Animal models of
schizophrenia are essential to gain a better understanding of the disease etiopathology and …

Antipsychotics represent the mainstay of schizophrenia pharmacological therapy, and their
role has been expanded in the last years to mood disorders treatment. Although introduced …

Recent studies suggest a primary role of oxidative stress in an early phase of the
pathogenesis of schizophrenia and a strong neurobiological link has been found between …

Severe mental illnesses (SMI) collectively affect approximately 20% of the global population,
as estimated by the World Health Organization (WHO). Despite having diverse etiologies …

Second-generation antipsychotics are the drugs of choice for the treatment of
neurodevelopmental-related mental diseases such as schizophrenia. Despite the …

It is known that continuous abuse of amphetamine (AMPH) results in alterations in neuronal
structure and cognitive behaviors related to the reward system. However, the impact of …

Investigating the biophysiological substrates of psychiatric illnesses is of great interest to our
understanding of disorders' etiology, the identification of reliable biomarkers, and potential …

Prefrontal cortex (PFC) inflammatory imbalance, oxidative/nitrosative stress (O/NS) and
impaired neuroplasticity in schizophrenia are thought to have neurodevelopmental origins …

Abnormal redox regulation is thought to contribute to schizophrenia (SCZ). Accumulating
studies have shown that the plasma antioxidant enzyme activity is closely associated with …

Schizophrenia is a devastating complex disorder characterised by a constellation of
behavioral deficits with the underlying mechanisms not fully known. Nitric oxide (NO) has …