This review article introduces mechanistic aspects and applications of photochemically
deprotected ortho-nitrobenzyl (ONB)-functionalized nucleic acids and their impact on …

Highlights•Hfq contacts RNA via proximal, distal, rim and C-terminal surfaces.•RNAs interact
with Hfq in multiple ways.•Mechanisms of Hfq-facilitated RNA pairing are being elucidated …

Hfq is a ubiquitous, Sm‐like RNA binding protein found in most bacteria and some archaea.
Hfq binds small regulatory RNAs (sRNAs), facilitates base pairing between sRNAs and their …

RNA-guided enzymes must quickly search a vast sequence space for their targets. This
search is aided by chaperones such as Hfq, a protein that mediates regulation by bacterial …

Stimuli-responsive polymeric depots capable of on-demand release of therapeutics promise
a substantial improvement in the treatment of many local diseases. These systems have the …

The bacterial Sm protein and RNA chaperone Hfq stabilizes small noncoding RNAs
(sRNAs) and facilitates their annealing to mRNA targets involved in stress tolerance and …

ABSTRACT RNA-binding proteins chaperone the biological functions of noncoding RNA by
reducing RNA misfolding, improving matchmaking between regulatory RNA and targets, and …

External photocontrol over RNA function has emerged as a useful tool for studying nucleic
acid biology. Most current methods rely on fully synthetic nucleic acids with photocaged …

The RNA chaperone Hfq is an Sm protein that facilitates base pairing between bacterial
small RNAs (sRNAs) and mRNAs involved in stress response and pathogenesis. Hfq …

Caged siRNAs with a single photolabile linker and/or vitamin E (vitE) modification at the 5′
terminal were rationally designed and synthesized. These virtually inactive caged siRNAs …