Isothermal amplification of nucleic acids is a simple process that rapidly and efficiently
accumulates nucleic acid sequences at constant temperature. Since the early 1990s …

Rolling circle amplification (RCA) is an efficient enzymatic isothermal reaction that using
circular probe as a template to generate long tandem single-stranded DNA or RNA products …

Increased glucose metabolism and reprogramming toward aerobic glycolysis are a hallmark
of cancer cells, meeting their metabolic needs for sustained cell proliferation. Metabolic …

Ten years ago, Hanahan and Weinberg delineated six “Hallmarks of cancer” which
summarize several decades of intense cancer research. However, tumor cells do not act in …

Highlights•∼ 2550 mRNA species are localized in dendrites and/or axons.•The alternative
usage of 3′ UTR isoforms dictates the fate of an mRNA molecule.•Novel multiplexed FISH …

The Hippo pathway is an evolutionarily conserved regulator of organ size and tumorigenesis
that negatively regulates cell growth and survival. Here we report that Yes-associated …

Angiogenesis does not only depend on endothelial cell invasion and proliferation: it also
requires pericyte coverage of vascular sprouts for vessel stabilization,. These processes are …

The activity of proteins is typically regulated by secondary modifications and by interactions
with other partners, resulting in the formation of protein complexes whose functions depend …

Hepatocyte cell death via apoptosis and necrosis are major hallmarks of ethanol‐induced
liver injury. However, inhibition of apoptosis is not sufficient to prevent ethanol‐induced …

Protein synthesis is a dynamic process that tunes the cellular proteome in response to
internal and external demands. Metabolic labeling approaches identify the general …