Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a major health problem,
with 10 million new cases diagnosed each year. Innate immunity plays an important role in …

Tuberculosis (TB) is considered a major worldwide health problem with 10 million new
cases diagnosed each year. Our understanding of TB immunology has become greater and …

Toll-like receptors (TLRs) are germ-line-encoded innate immune sensors that recognize
conserved microbial structures and host alarmins and signal expression of MHC proteins …

Mycobacterium tuberculosis is an extremely successful pathogen that appears to have
coevolved with humans as its specific host species for thousands of years (1). This persistent …

Tuberculosis associates with a wide spectrum of disease outcomes. The Bei**g (Bj) lineage
of Mycobacterium tuberculosis (Mtb) is suggested to be more virulent than other Mtb …

Toll-like receptors (TLRs) are pattern recognition receptors and play an important role in
innate immunity. Changes in TLRs and signaling molecules that result from polymorphisms …

Background Genetic factors are important contributors to the development of a wide range of
complex disease. Polymorphisms in genes encoding for toll-like receptors (TLRs) usually …

Upon the invasion of the host by microorganisms, innate immunity is triggered through
pathogen recognition by pattern recognition receptors (PRRs). Toll-like receptors (TLRs) are …

Abstract Background The function of Toll-like receptor 2 (TLR2) in host defense against
pathogens, especially Mycobacterium tuberculosis (Mtb) is poorly understood. To …

Abstract Background The control of Mycobacterium tuberculosis (Mtb) infection begins with
the recognition of mycobacterial structural components by toll like receptors (TLRs) and …