[HTML][HTML] Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation

NA Trayanova, A Lyon, J Shade… - Physiological …, 2023 - pmc.ncbi.nlm.nih.gov
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

Intercellular communication in the heart: therapeutic opportunities for cardiac ischemia

T Martins-Marques, DJ Hausenloy, JPG Sluijter… - Trends in molecular …, 2021 - cell.com
The maintenance of tissue, organ, and organism homeostasis relies on an intricate network
of players and mechanisms that assist in the different forms of cell–cell communication …

Purkinje network and myocardial substrate at the onset of human ventricular fibrillation: implications for catheter ablation

M Haissaguerre, G Cheniti, M Hocini… - European heart …, 2022 - academic.oup.com
Aims Map** data of human ventricular fibrillation (VF) are limited. We performed detailed
map** of the activities underlying the onset of VF and targeted ablation in patients with …

Cross-priming dendritic cells exacerbate immunopathology after ischemic tissue damage in the heart

E Forte, B Perkins, A Sintou, HS Kalkat… - Circulation, 2021 - Am Heart Assoc
Background: Ischemic heart disease is a leading cause of heart failure and despite
advanced therapeutic options, morbidity and mortality rates remain high. Although acute …

Mechanisms underlying antiarrhythmic properties of cardioprotective agents impacting inflammation and oxidative stress

K Andelova, BS Bacova, M Sykora, P Hlivak… - International Journal of …, 2022 - mdpi.com
The prevention of cardiac life-threatening ventricular fibrillation and stroke-provoking atrial
fibrillation remains a serious global clinical issue, with ongoing need for novel approaches …

From novel discovery tools and biomarkers to precision medicine—basic cardiovascular science highlights of 2021/22

PC Evans, SM Davidson, J Wojta, M Bäck… - Cardiovascular …, 2022 - academic.oup.com
Here, we review the highlights of cardiovascular basic science published in 2021 and early
2022 on behalf of the European Society of Cardiology Council for Basic Cardiovascular …

Atrial fibrosis and substrate based characterization in atrial fibrillation: time to move forwards

JX Quah, D Dharmaprani, K Tiver… - Journal of …, 2021 - Wiley Online Library
Atrial fibrillation (AF) is the most commonly encountered cardiac arrhythmia in clinical
practice. However, current therapeutic interventions for atrial fibrillation have limited clinical …

Different ventricular fibrillation types in low-dimensional latent spaces

CP Bernal Oñate, FM Melgarejo Meseguer, EV Carrera… - Sensors, 2023 - mdpi.com
The causes of ventricular fibrillation (VF) are not yet elucidated, and it has been proposed
that different mechanisms might exist. Moreover, conventional analysis methods do not …

Optical map** of contracting hearts

V Kappadan, A Sohi, U Parlitz, S Luther… - The Journal of …, 2023 - Wiley Online Library
Optical map** is a widely used tool to record and visualize the electrophysiological
properties in a variety of myocardial preparations such as Langendorff‐perfused isolated …

Right ventricular outflow tract electroanatomical abnormalities in asymptomatic and high‐risk symptomatic patients with Brugada syndrome: Evidence for a new risk …

KP Letsas, K Vlachos, G Conte… - Journal of …, 2021 - Wiley Online Library
Introduction Microstructural abnormalities at the epicardium of the right ventricular outflow
tract (RVOT) may provide the arrhythmia substrate in Brugada syndrome (BrS). Endocardial …