Evaluation of openai o1: Opportunities and challenges of agi
This comprehensive study evaluates the performance of OpenAI's o1-preview large
language model across a diverse array of complex reasoning tasks, spanning multiple …
language model across a diverse array of complex reasoning tasks, spanning multiple …
PomBase: a Global Core Biodata Resource—growth, collaboration, and sustainability
Abstract PomBase (https://www. pombase. org), the model organism database (MOD) for
fission yeast, was recently awarded Global Core Biodata Resource (GCBR) status by the …
fission yeast, was recently awarded Global Core Biodata Resource (GCBR) status by the …
BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance
Abstract Bacille Calmette–Guérin (BCG) vaccination can confer nonspecific protection
against heterologous pathogens. However, the underlying mechanisms remain mysterious …
against heterologous pathogens. However, the underlying mechanisms remain mysterious …
InterPro: the protein sequence classification resource in 2025<? mode longmeta?>
Abstract InterPro (https://www. ebi. ac. uk/interpro) is a freely accessible resource for the
classification of protein sequences into families. It integrates predictive models, known as …
classification of protein sequences into families. It integrates predictive models, known as …
AnnoPRO: a strategy for protein function annotation based on multi-scale protein representation and a hybrid deep learning of dual-path encoding
Protein function annotation has been one of the longstanding issues in biological sciences,
and various computational methods have been developed. However, the existing methods …
and various computational methods have been developed. However, the existing methods …
DisProt in 2024: improving function annotation of intrinsically disordered proteins
Abstract DisProt (URL: https://disprot. org) is the gold standard database for intrinsically
disordered proteins and regions, providing valuable information about their functions. The …
disordered proteins and regions, providing valuable information about their functions. The …
Ultrasound frequency-controlled microbubble dynamics in brain vessels regulate the enrichment of inflammatory pathways in the blood-brain barrier
Microbubble-enhanced ultrasound provides a noninvasive physical method to locally
overcome major obstacles to the accumulation of blood-borne therapeutics in the brain …
overcome major obstacles to the accumulation of blood-borne therapeutics in the brain …
An integrated transcriptomic cell atlas of human neural organoids
Human neural organoids, generated from pluripotent stem cells in vitro, are useful tools to
study human brain development, evolution and disease. However, it is unclear which parts …
study human brain development, evolution and disease. However, it is unclear which parts …
The Monarch Initiative in 2024: an analytic platform integrating phenotypes, genes and diseases across species
TE Putman, K Schaper, N Matentzoglu… - Nucleic acids …, 2024 - academic.oup.com
Bridging the gap between genetic variations, environmental determinants, and phenotypic
outcomes is critical for supporting clinical diagnosis and understanding mechanisms of …
outcomes is critical for supporting clinical diagnosis and understanding mechanisms of …
The STRING database in 2025: protein networks with directionality of regulation
Proteins cooperate, regulate and bind each other to achieve their functions. Understanding
the complex network of their interactions is essential for a systems-level description of …
the complex network of their interactions is essential for a systems-level description of …