Diffusion MRI (dMRI) has proven to be a useful imaging approach for both clinical diagnosis
and research investigating the microstructures of nervous tissues, and it has helped us to …

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide and is a risk
factor for dementia later in life. Research into the pathophysiology of TBI has focused on the …

Whereas the cerebral cortex has long been regarded by neuroscientists as the major locus
of cognitive function, the white matter of the brain is increasingly recognized as equally …

White matter (WM) occupies a large volume of the human cerebrum and is mainly composed
of myelinated axons and myelin-producing glial cells. The myelinated axons within WM are …

Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-
modulated transcription factor that governs the expression of genes involved in …

White matter fiber tracking using diffusion magnetic resonance imaging (dMRI) provides a
noninvasive approach to map brain connections, but improving anatomical accuracy has …

Multiple Sclerosis (MS) is an immune-mediated neurological disorder, characterized by
central nervous system (CNS) inflammation, oligodendrocyte loss, demyelination, and …

Background The secondary injury caused by traumatic brain injury (TBI), especially white
matter injury (WMI), is highly sensitive to neuroinflammation, which further leads to …

This article provides a review of brain tissue alterations that may be detectable using
diffusion magnetic resonance imaging MRI (dMRI) approaches and an overview and …

Every year in the United States, millions of individuals incur ischemic brain injury from
stroke, cardiac arrest, or traumatic brain injury (TBI). These forms of acquired brain injury can …