Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air.
CE Boström, P Gerde, A Hanberg… - Environmental …, 2002 - ehp.niehs.nih.gov
Polycyclic aromatic hydrocarbons (PAHs) are formed during incomplete combustion.
Domestic wood burning and road traffic are the major sources of PAHs in Sweden. In …
Domestic wood burning and road traffic are the major sources of PAHs in Sweden. In …
Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition
GK Dresser, JD Spence, DG Bailey - Clinical pharmacokinetics, 2000 - Springer
Drug interactions occur when the efficacy or toxicity of a medication is changed by
administration of another substance. Pharmacokinetic interactions often occur as a result of …
administration of another substance. Pharmacokinetic interactions often occur as a result of …
Inhaled therapy in respiratory disease: the complex interplay of pulmonary kinetic processes
JM Borghardt, C Kloft, A Sharma - Canadian respiratory journal, 2018 - Wiley Online Library
The inhalation route is frequently used to administer drugs for the management of
respiratory diseases such as asthma or chronic obstructive pulmonary disease. Compared …
respiratory diseases such as asthma or chronic obstructive pulmonary disease. Compared …
Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts
X Ding, LS Kaminsky - Annual review of pharmacology and …, 2003 - annualreviews.org
Cytochrome P450 (CYP) enzymes in extrahepatic tissues often play a dominant role in
target tissue metabolic activation of xenobiotic compounds. They may also determine drug …
target tissue metabolic activation of xenobiotic compounds. They may also determine drug …
Lipid nanoparticles as delivery vehicles for inhaled therapeutics
EWX Leong, R Ge - Biomedicines, 2022 - mdpi.com
Lipid nanoparticles (LNPs) have emerged as a powerful non-viral carrier for drug delivery.
With the prevalence of respiratory diseases, particularly highlighted by the current COVID-19 …
With the prevalence of respiratory diseases, particularly highlighted by the current COVID-19 …
Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung
Pathogenesis of lung diseases, such as lung cancer and chronic obstructive pulmonary
disease, is tightly linked to exposure to environmental chemicals, most notably tobacco …
disease, is tightly linked to exposure to environmental chemicals, most notably tobacco …
Role of P‐glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics
VJ Wacher, JA Silverman, Y Zhang… - Journal of …, 1998 - Wiley Online Library
Abstract Cytochrome P450 3A4 (CYP3A4), the major phase I drug metabolizing enzyme in
humans, and the MDR1 gene product P‐glycoprotein (P‐gp) are present at high …
humans, and the MDR1 gene product P‐glycoprotein (P‐gp) are present at high …
Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues
P Pavek, Z Dvorak - Current drug metabolism, 2008 - ingentaconnect.com
Numerous members of the cytochrome P450 (CYP) superfamily are induced after exposure
to a variety of xenobiotics in human liver. We have gained considerable mechanistic insights …
to a variety of xenobiotics in human liver. We have gained considerable mechanistic insights …
Pulmonary drug metabolism, clearance, and absorption
B Olsson, E Bondesson, L Borgström… - … pulmonary drug delivery, 2011 - Springer
Delivering therapeutic agents to the lungs requires a deep understanding of the kinetics and
dynamics of drugs in this biologically and physiologically complex system. In this chapter …
dynamics of drugs in this biologically and physiologically complex system. In this chapter …
Genetic variability in CYP3A5 and its possible consequences
The cytochrome P450 3A (CYP3A) subfamily members are the most abundant and important
drug-metabolizing enzymes in humans, and wide interindividual variability in CYP3A …
drug-metabolizing enzymes in humans, and wide interindividual variability in CYP3A …