Since its initial identification in 1992 as a possible class 1 cell-surface receptor without a
known parent ligand, receptor tyrosine kinase–like orphan receptor 1 (ROR1) has stimulated …

Wnts comprise a large family of proteins that have shown to be part of a signaling cascade
that regulates several aspects of development including organogenesis, midbrain …

Aging involves the deterioration of organismal function, leading to the emergence of multiple
pathologies. Environmental stimuli, including lifestyle, can influence the trajectory of this …

Evolutionarily conserved receptor tyrosine kinase–like orphan receptor-1 and-2 (ROR1/2)
are considered distinct receptors for Wnt5a and are implicated in noncanonical Wnt …

In addition to activating β-catenin/TCF transcriptional complexes, Wnt proteins can elicit a
variety of other responses. These are often lumped together under the denominator …

The first mammalian Wnt to be discovered, Wnt-1, was found to be essential for the
development of a large part of the mouse brain over 25 years ago. We have since learned …

Growing evidence indicates that Wingless-type (Wnt) signaling plays an important role in the
maturation of the central nervous system. We report here that Wingless-type family member …

Regulation of cell signaling by Wnt proteins is critical for the formation of neuronal circuits.
Wnts modulate axon pathfinding, dendritic development, and synaptic assembly. Through …

Members of the Wnt family of secreted signaling proteins influence many aspects of neural
development and function. Wnts are required from neural induction and axis formation to …

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the ROR family
consisting of ROR1 and ROR2. RORs contain two distinct extracellular cysteine-rich …