The gut microbiome as a modulator of healthy ageing

TS Ghosh, F Shanahan, PW O'Toole - … Reviews Gastroenterology & …, 2022 - nature.com
The gut microbiome is a contributory factor in ageing-related health loss and in several non-
communicable diseases in all age groups. Some age-linked and disease-linked …

Mitochondrial dynamics in health and disease: mechanisms and potential targets

W Chen, H Zhao, Y Li - Signal transduction and targeted therapy, 2023 - nature.com
Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …

The landscape of aging

Y Cai, W Song, J Li, Y **g, C Liang, L Zhang… - Science China Life …, 2022 - Springer
Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

An insight into gut microbiota and its functionalities

A Adak, MR Khan - Cellular and Molecular Life Sciences, 2019 - Springer
Gut microbiota has evolved along with their hosts and is an integral part of the human body.
Microbiota acquired at birth develops in parallel as the host develops and maintains its …

Microbiota and the social brain

E Sherwin, SR Bordenstein, JL Quinn, TG Dinan… - Science, 2019 - science.org
BACKGROUND Increasingly, it is recognized that the microbes resident in the
gastrointestinal tract can influence brain physiology and behavior. Research has shown that …

Gut microbiome and aging: Physiological and mechanistic insights

R Nagpal, R Mainali, S Ahmadi, S Wang… - … and healthy aging, 2018 - content.iospress.com
The development of human gut microbiota begins as soon as the neonate leaves the
protective environment of the uterus (or maybe in-utero) and is exposed to innumerable …

The gut microbiota and healthy aging: a mini-review

S Kim, SM Jazwinski - Gerontology, 2018 - karger.com
The gut microbiota shows a wide inter-individual variation, but its within-individual variation
is relatively stable over time. A functional core microbiome, provided by abundant bacterial …

Our gut microbiome: the evolving inner self

P Kundu, E Blacher, E Elinav, S Pettersson - Cell, 2017 - cell.com
The" holobiont" concept, defined as the collective contribution of the eukaryotic and
prokaryotic counterparts to the multicellular organism, introduces a complex definition of …

Senolytic combination of dasatinib and quercetin alleviates intestinal senescence and inflammation and modulates the gut microbiome in aged mice

TD Saccon, R Nagpal, H Yadav… - The Journals of …, 2021 - academic.oup.com
Cellular senescence contributes to age-related disorders including physical dysfunction,
disabilities, and mortality caused by tissue inflammation and damage. Senescent cells …

Age‐related changes in the gut microbiota influence systemic inflammation and stroke outcome

MS Spychala, VR Venna, M Jandzinski… - Annals of …, 2018 - Wiley Online Library
Objective Chronic systemic inflammation contributes to the pathogenesis of many age‐
related diseases. Although not well understood, alterations in the gut microbiota, or …