Strategies to address low drug solubility in discovery and development

HD Williams, NL Trevaskis, SA Charman… - Pharmacological …, 2013 - Elsevier
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

[HTML][HTML] Direct and reverse pluronic micelles: design and characterization of promising drug delivery nanosystems

A Naharros-Molinero, MÁ Caballo-González… - Pharmaceutics, 2022 - mdpi.com
Pluronics are a family of amphiphilic block copolymers broadly explored in the
pharmaceutical field. Under certain conditions, Pluronics self-assemble in different …

Topology-directed control on thermal stability: micelles formed from linear and cyclized amphiphilic block copolymers

S Honda, T Yamamoto, Y Tezuka - Journal of the American …, 2010 - ACS Publications
The thermal stability of a self-assembled micelle was remarkably enhanced by a topology
effect. Linear poly (butyl acrylate)-block-poly (ethylene oxide)-block-poly (butyl acrylate)(1) …

Micelles from PEO–PPO–PEO block copolymers as nanocontainers for solubilization of a poorly water soluble drug hydrochlorothiazide

Y Kadam, U Yerramilli, A Bahadur… - Colloids and Surfaces B …, 2011 - Elsevier
The effect of molecular characteristics of EO–PO triblock copolymers viz. Pluronic® P103
(EO17PO60PEO17), P123 (EO19PO69EO19), and F127 (EO100PO65EO100) on micellar …

Influence of additives on thermoresponsive polymers in aqueous media: a case study of poly (N-isopropylacrylamide)

R Umapathi, PM Reddy, A Rani… - Physical Chemistry …, 2018 - pubs.rsc.org
Thermoresponsive polymers (TRPs) in different solvent media have been studied over a
long period and are important from both scientific and technical points of view. Despite …

Structural characterization of Pluronic micelles swollen with perfume molecules

I Grillo, I Morfin, S Prévost - Langmuir, 2018 - ACS Publications
The insertion in nonionic polymer micelles (Pluronics F127) of seven essential oils and
some of the pure compounds that compose them was investigated by complementary …

Exploration of phase separation and several physicochemical parameters of the mixture of triton X-100 and ceftriaxone sodium salt: influences of the composition of …

MRI Rony, JM Khan, MR Islam, KMK Alam, D Kumar… - Chemical Papers, 2024 - Springer
Herein, the phase partitioning of triton X-100 (TX-100) and ceftriaxone sodium trihydrate
(CTS) drug mixture in aqueous solutions of sodium salts was thoroughly investigated. The …

Modulating effect of different biomolecules and other additives on cloud point and aggregation of amphiphilic linear and starblock copolymer

P Patidar, A Bahadur - Journal of Molecular Liquids, 2018 - Elsevier
Non-ionic surfactants based on ethylene oxide-propylene oxide (EO-PO) block copolymers
find applications in various industries including pharmaceutics, cosmetics, cleaning and …

Effect of ethanol on the gelation of aqueous solutions of Pluronic F127

C Chaibundit, NMPS Ricardo, NMPS Ricardo… - Journal of colloid and …, 2010 - Elsevier
In dilute aqueous solution unimers of copolymer F127 (E98P67E98) associate to form
micelles, and in more concentrated solution micelles pack to form high-modulus gels …

Pluronic®-bile salt mixed micelles

V Patel, D Ray, A Bahadur, J Ma, VK Aswal… - Colloids and Surfaces B …, 2018 - Elsevier
The present study was aimed to examine the interaction of two bile salts viz. sodium cholate
(NaC) and sodium deoxycholate (NaDC) with three ethylene polyoxide-polypropylene …