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Strategies to address low drug solubility in discovery and development
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …
therefore, to variability in clinical response. Despite significant efforts to “design in” …
[HTML][HTML] Direct and reverse pluronic micelles: design and characterization of promising drug delivery nanosystems
A Naharros-Molinero, MÁ Caballo-González… - Pharmaceutics, 2022 - mdpi.com
Pluronics are a family of amphiphilic block copolymers broadly explored in the
pharmaceutical field. Under certain conditions, Pluronics self-assemble in different …
pharmaceutical field. Under certain conditions, Pluronics self-assemble in different …
Topology-directed control on thermal stability: micelles formed from linear and cyclized amphiphilic block copolymers
S Honda, T Yamamoto, Y Tezuka - Journal of the American …, 2010 - ACS Publications
The thermal stability of a self-assembled micelle was remarkably enhanced by a topology
effect. Linear poly (butyl acrylate)-block-poly (ethylene oxide)-block-poly (butyl acrylate)(1) …
effect. Linear poly (butyl acrylate)-block-poly (ethylene oxide)-block-poly (butyl acrylate)(1) …
Micelles from PEO–PPO–PEO block copolymers as nanocontainers for solubilization of a poorly water soluble drug hydrochlorothiazide
Y Kadam, U Yerramilli, A Bahadur… - Colloids and Surfaces B …, 2011 - Elsevier
The effect of molecular characteristics of EO–PO triblock copolymers viz. Pluronic® P103
(EO17PO60PEO17), P123 (EO19PO69EO19), and F127 (EO100PO65EO100) on micellar …
(EO17PO60PEO17), P123 (EO19PO69EO19), and F127 (EO100PO65EO100) on micellar …
Influence of additives on thermoresponsive polymers in aqueous media: a case study of poly (N-isopropylacrylamide)
R Umapathi, PM Reddy, A Rani… - Physical Chemistry …, 2018 - pubs.rsc.org
Thermoresponsive polymers (TRPs) in different solvent media have been studied over a
long period and are important from both scientific and technical points of view. Despite …
long period and are important from both scientific and technical points of view. Despite …
Structural characterization of Pluronic micelles swollen with perfume molecules
The insertion in nonionic polymer micelles (Pluronics F127) of seven essential oils and
some of the pure compounds that compose them was investigated by complementary …
some of the pure compounds that compose them was investigated by complementary …
Exploration of phase separation and several physicochemical parameters of the mixture of triton X-100 and ceftriaxone sodium salt: influences of the composition of …
Herein, the phase partitioning of triton X-100 (TX-100) and ceftriaxone sodium trihydrate
(CTS) drug mixture in aqueous solutions of sodium salts was thoroughly investigated. The …
(CTS) drug mixture in aqueous solutions of sodium salts was thoroughly investigated. The …
Modulating effect of different biomolecules and other additives on cloud point and aggregation of amphiphilic linear and starblock copolymer
P Patidar, A Bahadur - Journal of Molecular Liquids, 2018 - Elsevier
Non-ionic surfactants based on ethylene oxide-propylene oxide (EO-PO) block copolymers
find applications in various industries including pharmaceutics, cosmetics, cleaning and …
find applications in various industries including pharmaceutics, cosmetics, cleaning and …
Effect of ethanol on the gelation of aqueous solutions of Pluronic F127
C Chaibundit, NMPS Ricardo, NMPS Ricardo… - Journal of colloid and …, 2010 - Elsevier
In dilute aqueous solution unimers of copolymer F127 (E98P67E98) associate to form
micelles, and in more concentrated solution micelles pack to form high-modulus gels …
micelles, and in more concentrated solution micelles pack to form high-modulus gels …
Pluronic®-bile salt mixed micelles
The present study was aimed to examine the interaction of two bile salts viz. sodium cholate
(NaC) and sodium deoxycholate (NaDC) with three ethylene polyoxide-polypropylene …
(NaC) and sodium deoxycholate (NaDC) with three ethylene polyoxide-polypropylene …