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Oxidative stress in intervertebral disc degeneration: molecular mechanisms, pathogenesis and treatment
Y Wang, H Cheng, T Wang, K Zhang, Y Zhang… - Cell …, 2023 - Wiley Online Library
Low back pain (LBP) is a leading cause of labour loss and disability worldwide, and it also
imposes a severe economic burden on patients and society. Among symptomatic LBP …
imposes a severe economic burden on patients and society. Among symptomatic LBP …
NF‐κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration
GZ Zhang, MQ Liu, HW Chen, ZL Wu, YC Gao… - Cell …, 2021 - Wiley Online Library
Intervertebral disc degeneration (IDD) is a common clinical degenerative disease of the
spine. A series of factors, such as inflammation, oxidative stress and mechanical stress …
spine. A series of factors, such as inflammation, oxidative stress and mechanical stress …
Causal associations of obesity with the intervertebral degeneration, low back pain, and sciatica: a two-sample Mendelian randomization study
J Zhou, J Mi, Y Peng, H Han, Z Liu - Frontiers in endocrinology, 2021 - frontiersin.org
The role of obesity in the development of dorsopathies is still unclear. In this study, we
assessed the associations between body mass index (BMI) and several dorsopathies …
assessed the associations between body mass index (BMI) and several dorsopathies …
The role of nerve fibers and their neurotransmitters in regulating intervertebral disc degeneration
K Sun, J Jiang, Y Wang, X Sun, J Zhu, X Xu… - Ageing Research …, 2022 - Elsevier
Intervertebral disc degeneration (IVDD) has been the major contributor to chronic lower back
pain (LBP). Abnormal apoptosis, senescence, and pyroptosis of IVD cells, extracellular …
pain (LBP). Abnormal apoptosis, senescence, and pyroptosis of IVD cells, extracellular …
Glutamine suppresses senescence and promotes autophagy through glycolysis inhibition-mediated AMPKα lactylation in intervertebral disc degeneration
Y Zhang, Z Huang, W Han, J Wu, S Li, T Qin… - Communications …, 2024 - nature.com
Regulating metabolic disorders has become a promising focus in treating intervertebral disc
degeneration (IDD). A few drugs regulating metabolism, such as atorvastatin, metformin, and …
degeneration (IDD). A few drugs regulating metabolism, such as atorvastatin, metformin, and …
Understanding the etiopathogenesis of lumbar intervertebral disc herniation: From clinical evidence to basic scientific research
Lumbar intervertebral disc herniation, as a leading cause of low back pain, productivity loss,
and disability, is a common musculoskeletal disorder that results in significant …
and disability, is a common musculoskeletal disorder that results in significant …
The importance of inflammatory biomarkers in non-specific acute and chronic low back pain: a systematic review
EM Pinto, JR Neves, M Laranjeira, J Reis - European Spine Journal, 2023 - Springer
Objective The purpose of this study was to systematically review the evidence on
inflammatory biomarkers as analytic predictors of non-specific low back pain (NsLBP) …
inflammatory biomarkers as analytic predictors of non-specific low back pain (NsLBP) …
[HTML][HTML] Beneficial effects of physical activity in diabetic patients
One of the main goals of diabetic therapy is to achieve the best metabolic control to prevent
the development and progression of potential complications. A multidisciplinary approach …
the development and progression of potential complications. A multidisciplinary approach …
The burden of low back pain in children and adolescents with overweight and obesity: from pathophysiology to prevention and treatment strategies
Nonspecific low back pain (LBP) is one of the most common causes of disability, affecting all
individuals at least once in their lifetime. Such a condition is also becoming increasingly …
individuals at least once in their lifetime. Such a condition is also becoming increasingly …
Diabetes and intervertebral disc degeneration: A Mendelian randomization study
P **, Y **ng, B **ao, Y Wei, K Yan, J Zhao… - Frontiers in …, 2023 - frontiersin.org
Introduction Intervertebral disc degeneration (IVDD) is an important contributor of low back
pain, which represents one of the most disabling symptoms within the adult population …
pain, which represents one of the most disabling symptoms within the adult population …