Oxidative stress in intervertebral disc degeneration: molecular mechanisms, pathogenesis and treatment

Y Wang, H Cheng, T Wang, K Zhang, Y Zhang… - Cell …, 2023 - Wiley Online Library
Low back pain (LBP) is a leading cause of labour loss and disability worldwide, and it also
imposes a severe economic burden on patients and society. Among symptomatic LBP …

NF‐κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration

GZ Zhang, MQ Liu, HW Chen, ZL Wu, YC Gao… - Cell …, 2021 - Wiley Online Library
Intervertebral disc degeneration (IDD) is a common clinical degenerative disease of the
spine. A series of factors, such as inflammation, oxidative stress and mechanical stress …

Causal associations of obesity with the intervertebral degeneration, low back pain, and sciatica: a two-sample Mendelian randomization study

J Zhou, J Mi, Y Peng, H Han, Z Liu - Frontiers in endocrinology, 2021 - frontiersin.org
The role of obesity in the development of dorsopathies is still unclear. In this study, we
assessed the associations between body mass index (BMI) and several dorsopathies …

The role of nerve fibers and their neurotransmitters in regulating intervertebral disc degeneration

K Sun, J Jiang, Y Wang, X Sun, J Zhu, X Xu… - Ageing Research …, 2022 - Elsevier
Intervertebral disc degeneration (IVDD) has been the major contributor to chronic lower back
pain (LBP). Abnormal apoptosis, senescence, and pyroptosis of IVD cells, extracellular …

Glutamine suppresses senescence and promotes autophagy through glycolysis inhibition-mediated AMPKα lactylation in intervertebral disc degeneration

Y Zhang, Z Huang, W Han, J Wu, S Li, T Qin… - Communications …, 2024 - nature.com
Regulating metabolic disorders has become a promising focus in treating intervertebral disc
degeneration (IDD). A few drugs regulating metabolism, such as atorvastatin, metformin, and …

Understanding the etiopathogenesis of lumbar intervertebral disc herniation: From clinical evidence to basic scientific research

M Zhou, AA Theologis, GD O'Connell - JOR spine, 2024 - Wiley Online Library
Lumbar intervertebral disc herniation, as a leading cause of low back pain, productivity loss,
and disability, is a common musculoskeletal disorder that results in significant …

The importance of inflammatory biomarkers in non-specific acute and chronic low back pain: a systematic review

EM Pinto, JR Neves, M Laranjeira, J Reis - European Spine Journal, 2023 - Springer
Objective The purpose of this study was to systematically review the evidence on
inflammatory biomarkers as analytic predictors of non-specific low back pain (NsLBP) …

[HTML][HTML] Beneficial effects of physical activity in diabetic patients

F Cannata, G Vadalà, F Russo, R Papalia… - Journal of functional …, 2020 - mdpi.com
One of the main goals of diabetic therapy is to achieve the best metabolic control to prevent
the development and progression of potential complications. A multidisciplinary approach …

The burden of low back pain in children and adolescents with overweight and obesity: from pathophysiology to prevention and treatment strategies

L Ambrosio, G Mazzuca, A Maguolo… - Therapeutic …, 2023 - journals.sagepub.com
Nonspecific low back pain (LBP) is one of the most common causes of disability, affecting all
individuals at least once in their lifetime. Such a condition is also becoming increasingly …

Diabetes and intervertebral disc degeneration: A Mendelian randomization study

P **, Y **ng, B **ao, Y Wei, K Yan, J Zhao… - Frontiers in …, 2023 - frontiersin.org
Introduction Intervertebral disc degeneration (IVDD) is an important contributor of low back
pain, which represents one of the most disabling symptoms within the adult population …