[HTML][HTML] Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing
The recent advent of microphysiological systems–microfluidic biomimetic devices that aspire
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …
Liver 'organ on a chip'
The liver plays critical roles in both homeostasis and pathology. It is the major site of drug
metabolism in the body and, as such, a common target for drug-induced toxicity and is …
metabolism in the body and, as such, a common target for drug-induced toxicity and is …
In vitro models for liver toxicity testing
VY Soldatow, EL LeCluyse, LG Griffith… - Toxicology …, 2013 - academic.oup.com
Over the years, various liver-derived in vitro model systems have been developed to enable
investigation of the potential adverse effects of chemicals and drugs. Liver tissue slices …
investigation of the potential adverse effects of chemicals and drugs. Liver tissue slices …
3D bioprinting of tissue/organ models
In vitro tissue/organ models are useful platforms that can facilitate systematic, repetitive, and
quantitative investigations of drugs/chemicals. The primary objective when develo** …
quantitative investigations of drugs/chemicals. The primary objective when develo** …
Cell and tissue engineering for liver disease
Despite the tremendous hurdles presented by the complexity of the liver's structure and
function, advances in liver physiology, stem cell biology and reprogramming, and the …
function, advances in liver physiology, stem cell biology and reprogramming, and the …
Organotypic liver culture models: meeting current challenges in toxicity testing
EL LeCluyse, RP Witek, ME Andersen… - Critical reviews in …, 2012 - Taylor & Francis
Prediction of chemical-induced hepatotoxicity in humans from in vitro data continues to be a
significant challenge for the pharmaceutical and chemical industries. Generally …
significant challenge for the pharmaceutical and chemical industries. Generally …
The endothelium as a driver of liver fibrosis and regeneration
E Lafoz, M Ruart, A Anton, A Oncins, V Hernández-Gea - Cells, 2020 - mdpi.com
Liver fibrosis is a common feature of sustained liver injury and represents a major public
health problem worldwide. Fibrosis is an active research field and discoveries in the last …
health problem worldwide. Fibrosis is an active research field and discoveries in the last …
Perfused multiwell plate for 3D liver tissue engineering
K Domansky, W Inman, J Serdy, A Dash, MHM Lim… - Lab on a Chip, 2010 - pubs.rsc.org
In vitro models that capture the complexity of in vivo tissue and organ behaviors in a
scalable and easy-to-use format are desirable for drug discovery. To address this, we have …
scalable and easy-to-use format are desirable for drug discovery. To address this, we have …
[HTML][HTML] Bioengineered liver models for drug testing and cell differentiation studies
In vitro models of the human liver are important for the following:(1) mitigating the risk of drug-
induced liver injury to human beings,(2) modeling human liver diseases,(3) elucidating the …
induced liver injury to human beings,(2) modeling human liver diseases,(3) elucidating the …
Microfluidic models of vascular functions
In vitro studies of vascular physiology have traditionally relied on cultures of endothelial
cells, smooth muscle cells, and pericytes grown on centimeter-scale plates, filters, and flow …
cells, smooth muscle cells, and pericytes grown on centimeter-scale plates, filters, and flow …