Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

B Niu, K Liao, Y Zhou, T Wen, G Quan, X Pan, C Wu - Biomaterials, 2021 - Elsevier
Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a
high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) …

Chemodynamic therapy via fenton and fenton‐like nanomaterials: strategies and recent advances

C Jia, Y Guo, FG Wu - Small, 2022 - Wiley Online Library
Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment
using Fenton or Fenton‐like reaction to produce• OH in the tumor region, was first proposed …

Manipulating intratumoral fenton chemistry for enhanced chemodynamic and chemodynamic‐synergized multimodal therapy

Y Zhou, S Fan, L Feng, X Huang, X Chen - Advanced Materials, 2021 - Wiley Online Library
Chemodynamic therapy (CDT) uses the tumor microenvironment‐assisted intratumoral
Fenton reaction for generating highly toxic hydroxyl free radicals (• OH) to achieve selective …

Near-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy

B Geng, J Hu, Y Li, S Feng, D Pan, L Feng… - Nature …, 2022 - nature.com
Theranostic sonosensitizers with combined sonodynamic and near infrared (NIR) imaging
modes are required for imaging guided sonodynamic therapy (SDT). It is challenging …

Synergistic antibacterial strategy based on photodynamic therapy: Progress and perspectives

X Hu, H Zhang, Y Wang, BC Shiu, JH Lin… - Chemical Engineering …, 2022 - Elsevier
The dramatic increase in drug resistant bacteria resistance to existing conventional
antibiotics poses a great challenge to the effective treatment of infectious diseases …

One-step integration of tumor microenvironment-responsive calcium and copper peroxides nanocomposite for enhanced chemodynamic/ion-interference therapy

B Liu, Y Bian, S Liang, M Yuan, S Dong, F He, S Gai… - ACS …, 2021 - ACS Publications
Recently, various metal peroxide nanomaterials have drawn increasing attention as an
efficient hydrogen peroxide (H2O2) self-supplying agent for enhanced tumor therapy …

Nanozymes: versatile platforms for cancer diagnosis and therapy

X Zhang, X Chen, Y Zhao - Nano-Micro Letters, 2022 - Springer
Natural enzymes usually suffer from high production cost, ease of denaturation and
inactivation, and low yield, making them difficult to be broadly applicable. As an emerging …

Architecture of Vanadium‐Based MXene Dysregulating Tumor Redox Homeostasis for Amplified Nanozyme Catalytic/Photothermal Therapy

R Zhao, Y Zhu, L Feng, B Liu, Y Hu, H Zhu… - Advanced …, 2024 - Wiley Online Library
Taking the significance of the special microenvironment for tumor cell survival into account,
disrupting tumor redox homeostasis is highly prospective for improving therapeutic efficacy …

Strategies for enhancing cancer chemodynamic therapy performance

D Jana, Y Zhao - Exploration, 2022 - Wiley Online Library
Chemodynamic therapy (CDT) has emerged to be a frontrunner amongst reactive oxygen
species‐based cancer treatment modalities. CDT utilizes endogenous H2O2 in tumor …

A cascade nanozyme with amplified sonodynamic therapeutic effects through comodulation of hypoxia and immunosuppression against cancer

N Tao, H Li, L Deng, S Zhao, J Ouyang, M Wen… - ACS …, 2021 - ACS Publications
The tumor microenvironment (TME) featured by immunosuppression and hypoxia is pivotal
to cancer deterioration and metastasis. Thus, regulating the TME to improve cancer cell …