Cardiac fibrosis is central to the pathology of heart failure, particularly heart failure with
preserved ejection fraction (HF p EF). Irrespective of the underlying profibrotic condition (eg …

Myocardial fibrosis is a remodeling process of the extracellular matrix (ECM) following
cardiac stress.“Replacement fibrosis” is a term used to describe wound healing in the acute …

Myocardial interstitial fibrosis (MIF) is a histological hallmark of several cardiac diseases that
alter myocardial architecture and function and are associated with progression to heart …

Cardiac fibrosis is characterized by the deposition of extracellular matrix proteins in the
spaces between cardiomyocytes following both acute and chronic tissue damage events …

Dysregulated mitochondrial metabolism occurs in several pathological processes
characterized by cell proliferation and migration. Nonetheless, the role of mitochondrial …

Cardiac fibrosis is a common pathological consequence of most myocardial diseases. It is
associated with the excessive accumulation of extracellular matrix proteins as well as …

Pathological cardiac hypertrophy is a key risk factor for the development of heart failure and
predisposes individuals to cardiac arrhythmia and sudden death. While physiological …

Background Pulmonary hypertension (PH) results in increased right ventricular (RV)
afterload and ventricular remodeling. Sacubitril/valsartan (sac/val) is a dual acting drug …

Cardiac fibrosis constitutes irreversible necrosis of the heart muscle as a consequence of
different acute (myocardial infarction) or chronic (diabetes, hypertension,…) diseases but …

Background Exosomes are small extracellular vesicles that function as intercellular
messengers and effectors. Exosomal cargo contains regulatory small molecules, including …