COVID-19 transmission, current treatment, and future therapeutic strategies

VS Salian, JA Wright, PT Vedell, S Nair… - Molecular …, 2021 - ACS Publications
At the stroke of the New Year 2020, COVID-19, a zoonotic disease that would turn into a
global pandemic, was identified in the Chinese city of Wuhan. Although unique in its …

[HTML][HTML] Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

Y Huang, C Yang, X Xu, W Xu, S Liu - Acta Pharmacologica Sinica, 2020 - nature.com
Coronavirus disease 2019 is a newly emerging infectious disease currently spreading
across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome …

[HTML][HTML] Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies

CO Barnes, AP West, KE Huey-Tubman… - Cell, 2020 - cell.com
Neutralizing antibody responses to coronaviruses mainly target the receptor-binding domain
(RBD) of the trimeric spike. Here, we characterized polyclonal immunoglobulin Gs (IgGs) …

A review of SARS-CoV-2 and the ongoing clinical trials

YF Tu, CS Chien, AA Yarmishyn, YY Lin… - International journal of …, 2020 - mdpi.com
The sudden outbreak of 2019 novel coronavirus (2019-nCoV, later named SARS-CoV-2) in
Wuhan, China, which rapidly grew into a global pandemic, marked the third introduction of a …

Challenges in laboratory diagnosis of the novel coronavirus SARS-CoV-2

N Younes, DW Al-Sadeq, H Al-Jighefee, S Younes… - Viruses, 2020 - mdpi.com
The recent outbreak of the Coronavirus disease 2019 (COVID-19) has quickly spread
worldwide since its discovery in Wuhan city, China in December 2019. A comprehensive …

A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin

A Hasan, BA Paray, A Hussain, FA Qadir… - Journal of …, 2021 - Taylor & Francis
The widespread antigenic changes lead to the emergence of a new type of coronavirus
(CoV) called as severe acute respiratory syndrome (SARS)-CoV-2 that is immunologically …

A serological survey of SARS-CoV-2 in cat in Wuhan

Q Zhang, H Zhang, J Gao, K Huang… - Emerging microbes & …, 2020 - Taylor & Francis
ABSTRACT COVID-19 is a new respiratory illness caused by SARS-CoV-2, and has
constituted a global public health emergency. Cat is susceptible to SARS-CoV-2. However …

S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

JG Liang, D Su, TZ Song, Y Zeng, W Huang… - Nature …, 2021 - nature.com
SARS-CoV-2 is the underlying cause for the COVID-19 pandemic. Like most enveloped
RNA viruses, SARS-CoV-2 uses a homotrimeric surface antigen to gain entry into host cells …

[HTML][HTML] Artificial intelligence in the diagnosis of COVID-19: challenges and perspectives

S Huang, J Yang, S Fong, Q Zhao - International journal of …, 2021 - ncbi.nlm.nih.gov
Artificial intelligence (AI) is being used to aid in various aspects of the COVID-19 crisis,
including epidemiology, molecular research and drug development, medical diagnosis and …

[HTML][HTML] Mutations of SARS-CoV-2 spike protein: Implications on immune evasion and vaccine-induced immunity

HM Mengist, AJK Kombe, D Mekonnen, A Abebaw… - Seminars in …, 2021 - Elsevier
Responsible for more than 4.9 million deaths so far, COVID-19, caused by SARS-CoV-2, is
instigating devastating effects on the global health care system whose impacts could be …