Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized
by the degeneration of both upper and lower motor neurons, which leads to muscle …
by the degeneration of both upper and lower motor neurons, which leads to muscle …
Disruption of RNA metabolism in neurological diseases and emerging therapeutic interventions
RNA binding proteins are critical to the maintenance of the transcriptome via controlled
regulation of RNA processing and transport. Alterations of these proteins impact multiple …
regulation of RNA processing and transport. Alterations of these proteins impact multiple …
[HTML][HTML] Elimination of toxic microsatellite repeat expansion RNA by RNA-targeting Cas9
Microsatellite repeat expansions in DNA produce pathogenic RNA species that cause
dominantly inherited diseases such as myotonic dystrophy type 1 and 2 (DM1/2) …
dominantly inherited diseases such as myotonic dystrophy type 1 and 2 (DM1/2) …
The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains
An expanded GGGGCC hexanucleotide in C9ORF72 (C9) is the most frequent known cause
of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). It has been …
of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). It has been …
[HTML][HTML] Identification of therapeutic targets for amyotrophic lateral sclerosis using PandaOmics–an AI-enabled biological target discovery platform
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease with ill-defined
pathogenesis, calling for urgent developments of new therapeutic regimens. Herein, we …
pathogenesis, calling for urgent developments of new therapeutic regimens. Herein, we …
RNA toxicity in non‐coding repeat expansion disorders
Several neurodegenerative disorders like amyotrophic lateral sclerosis (ALS) and
spinocerebellar ataxia (SCA) are caused by non‐coding nucleotide repeat expansions …
spinocerebellar ataxia (SCA) are caused by non‐coding nucleotide repeat expansions …
Dysregulated molecular pathways in amyotrophic lateral sclerosis–frontotemporal dementia spectrum disorder
FB Gao, S Almeida, R Lopez‐Gonzalez - The EMBO journal, 2017 - embopress.org
Frontotemporal dementia (FTD), the second most common form of dementia in people under
65 years of age, is characterized by progressive atrophy of the frontal and/or temporal lobes …
65 years of age, is characterized by progressive atrophy of the frontal and/or temporal lobes …
A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism
The exact mechanism underlying amyotrophic lateral sclerosis (ALS) and frontotemporal
dementia (FTD) associated with the GGGGCC repeat expansion in C9orf72 is still unclear …
dementia (FTD) associated with the GGGGCC repeat expansion in C9orf72 is still unclear …
SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits
Hexanucleotide repeat expansions in the C9ORF72 gene are the commonest known
genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Expression of …
genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Expression of …
The genetics of amyotrophic lateral sclerosis: current insights
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that results
in loss of the upper and lower motor neurons from motor cortex, brainstem, and spinal cord …
in loss of the upper and lower motor neurons from motor cortex, brainstem, and spinal cord …