AI in the clinical management of GA: a novel therapeutic universe requires novel tools

GS Reiter, J Mai, S Riedl, K Birner, S Frank… - Progress in Retinal and …, 2024 - Elsevier
Regulatory approval of the first two therapeutic substances for the management of
geographic atrophy (GA) secondary to age-related macular degeneration (AMD) is a major …

The role of the retinal vasculature in age-related macular degeneration: a spotlight on OCTA

TRP Taylor, MJ Menten, D Rueckert, S Sivaprasad… - Eye, 2024 - nature.com
Age-related macular degeneration (AMD) remains a disease with high morbidity and an
incompletely understood pathophysiological mechanism. The ocular blood supply has been …

Automated deep learning-based AMD detection and staging in real-world OCT datasets (PINNACLE study report 5)

O Leingang, S Riedl, J Mai, GS Reiter, G Faustmann… - Scientific Reports, 2023 - nature.com
Real-world retinal optical coherence tomography (OCT) scans are available in abundance
in primary and secondary eye care centres. They contain a wealth of information to be …

Deep survival modeling of longitudinal retinal OCT volumes for predicting the onset of atrophy in patients with intermediate AMD

A Rivail, WD Vogl, S Riedl, C Grechenig… - Biomedical Optics …, 2023 - opg.optica.org
In patients with age-related macular degeneration (AMD), the risk of progression to late
stages is highly heterogeneous, and the prognostic imaging biomarkers remain unclear. We …

[HTML][HTML] Systematic review of prognostic factors associated with progression to late age-related macular degeneration: Pinnacle study report 2

AM Hagag, R Kaye, V Hoang, S Riedl, P Anders… - Survey of …, 2024 - Elsevier
There is a need to identify accurately prognostic factors that determine the progression of
intermediate to late-stage age-related macular degeneration (AMD). Currently, clinicians …

Topographic and quantitative correlation of structure and function using deep learning in subclinical biomarkers of intermediate age-related macular degeneration

K Birner, GS Reiter, I Steiner, G Deák, H Mohamed… - Scientific Reports, 2024 - nature.com
To examine the morphological impact of deep learning (DL)-quantified biomarkers on point-
wise sensitivity (PWS) using microperimetry (MP) and optical coherence tomography (OCT) …

3DTINC: Time-Equivariant Non-Contrastive Learning for Predicting Disease Progression from Longitudinal OCTs

T Emre, A Chakravarty, A Rivail… - … on Medical Imaging, 2024 - ieeexplore.ieee.org
Self-supervised learning (SSL) has emerged as a powerful technique for improving the
efficiency and effectiveness of deep learning models. Contrastive methods are a prominent …

[HTML][HTML] Deep Learning–Based Clustering of OCT Images for Biomarker Discovery in Age-Related Macular Degeneration (PINNACLE Study Report 4)

R Holland, R Kaye, AM Hagag, O Leingang… - Ophthalmology …, 2024 - Elsevier
Purpose We introduce a deep learning–based biomarker proposal system for the purpose of
accelerating biomarker discovery in age-related macular degeneration (AMD). Design …

[HTML][HTML] Generalizable deep learning for the detection of incomplete and complete retinal pigment epithelium and outer retinal atrophy: a Macustar report

C de Vente, P Valmaggia, CB Hoyng… - … Vision Science & …, 2024 - iovs.arvojournals.org
Purpose: The purpose of this study was to develop a deep learning algorithm for detecting
and quantifying incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) and …

Advanced therapy medicinal products for age-related macular degeneration; scaffold fabrication and delivery methods

H Khalili, HH Kashkoli, DE Weyland, S Pirkalkhoran… - Pharmaceuticals, 2023 - mdpi.com
Retinal degenerative diseases such as age-related macular degeneration (AMD) represent
a leading cause of blindness, resulting in permanent damage to retinal cells that are …