pH sensing at the intersection of tissue homeostasis and inflammation

S Hajjar, X Zhou - Trends in Immunology, 2023 - cell.com
Abstract pH is tightly maintained at cellular, tissue, and systemic levels, and altered pH–
particularly in the acidic range–is associated with infection, injury, solid tumors, and …

Recent advances in targeted therapy for inflammatory vascular diseases

K Zhao, Z Zeng, Y He, R Zhao, J Niu, H Sun, S Li… - Journal of Controlled …, 2024 - Elsevier
Vascular diseases constitute a significant contributor to worldwide mortality rates, placing a
substantial strain on healthcare systems and socio-economic aspects. They are closely …

Oxidative stress biomarker triggered multiplexed tool for auxiliary diagnosis of atherosclerosis

Y Ma, W Sun, Z Ye, L Liu, M Li, J Shang, X Xu… - Science …, 2023 - science.org
Oxidative stress is integral in the development of atherosclerosis, but knowledge of how
oxidative stress affects atherosclerosis remains insufficient. Here, we design a multiplexed …

A comparative study of ultrasmall calcium carbonate nanoparticles for targeting and imaging atherosclerotic plaque

L Martínez-Parra, M Piñol-Cancer, C Sanchez-Cano… - ACS …, 2023 - ACS Publications
Atherosclerosis is a complex disease that can lead to life-threatening events, such as
myocardial infarction and ischemic stroke. Despite the severity of this disease, diagnosing …

Red blood cell membrane biomimetic nanoprobes for ratiometric imaging of reactive oxygen species level in atherosclerosis

B Liu, GM Han, DX Wang, DB Liu, AA Liu… - Chemical Engineering …, 2024 - Elsevier
Atherosclerosis (AS) is a major pathological factor to cardiovascular diseases, wherein
reactive oxygen species (ROS) serve as the initiating link for the development of AS …

IgE contributes to atherosclerosis and obesity by affecting macrophage polarization, macrophage protein network, and foam cell formation

X Zhang, J Li, S Luo, M Wang, Q Huang… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: By binding to its high-affinity receptor FcεR1, IgE activates mast cells,
macrophages, and other inflammatory and vascular cells. Recent studies support an …

Exosomes as a messager to regulate the crosstalk between macrophages and cardiomyocytes under hypoxia conditions

Z Zhang, Y Xu, C Cao, B Wang, J Guo… - Journal of Cellular …, 2022 - Wiley Online Library
Recent studies have confirmed that cardiomyocyte‐derived exosomes have many pivotal
biological functions, like influencing the progress of coronary artery disease via modulating …

[HTML][HTML] Atherosclerosis: the involvement of immunity, cytokines and cells in pathogenesis, and potential novel therapeutics

C Su, Y Lu, Z Wang, J Guo, Y Hou, X Wang… - Aging and …, 2023 - ncbi.nlm.nih.gov
As a leading contributor to coronary artery disease (CAD) and stroke, atherosclerosis has
become one of the major cardiovascular diseases (CVD) negatively impacting patients …

SGLT2 inhibitors prevent LPS-induced M1 macrophage polarization and alleviate inflammatory bowel disease by downregulating NHE1 expression

YJ Kim, J **, DH Kim, D Kim, YM Lee, JK Byun… - Inflammation …, 2023 - Springer
Background Classically activated M1 macrophages, characterized by aberrant glycolysis
and secretion of inflammatory cytokines, play pivotal roles in inflammatory diseases …

Calcium carbonate nanoparticles stimulate cancer cell reprogramming to suppress tumor growth and invasion in an organ-on-a-chip system

SF Lam, KW Bishop, R Mintz, L Fang, S Achilefu - Scientific reports, 2021 - nature.com
The acidic microenvironment of solid tumors induces the propagation of highly invasive and
metastatic phenotypes. However, simulating these conditions in animal models present …