BACKGROUND Infertility and pregnancy loss are longstanding problems. Successful
fertilization and high-quality embryos are prerequisites for an ongoing pregnancy. Studies …

Emerging studies indicate that the Hippo pathway, a highly conserved pathway that
regulates organ size control, plays an important role in governing ovarian physiology …

In human embryos, the initiation of transcription (embryonic genome activation [EGA]) occurs
by the eight-cell stage, but its exact timing and profile are unclear. To address this, we …

Translational regulation plays a critical role during the oocyte-to-embryo transition (OET)
and zygotic genome activation (ZGA). Here, we integrated ultra-low-input ribosome profiling …

Although parental genomes undergo extensive epigenetic reprogramming to be equalized
after fertilization, whether they play different roles in human zygotic genome activation (ZGA) …

Abnormal resumption of meiosis and decreased oocyte quality are hallmarks of maternal
aging. Transcriptional silencing makes translational control an urgent task during meiosis …

In sexually reproducing organisms, life begins with the fusion of transcriptionally silent
gametes, the oocyte and sperm. Although initiation of transcription in the embryo, known as …

Early embryonic arrest and fragmentation (EEAF) is a common phenomenon leading to
female infertility, but the genetic determinants remain largely unknown. The Moloney …

Since its recent discovery, the subcortical maternal complex (SCMC) is emerging as a
maternally inherited and crucial biological structure for the initial stages of embryogenesis in …

STUDY QUESTION Which processes and transcription factors specify the first and second
lineage segregation events during human preimplantation development? SUMMARY …