The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities
Chronic, unresolved tissue inflammation is a well-described feature of obesity, type 2
diabetes mellitus (T2DM) and other insulin-resistant states. In this context, adipose tissue …
diabetes mellitus (T2DM) and other insulin-resistant states. In this context, adipose tissue …
Beta cell dysfunction and insulin resistance
Beta cell dysfunction and insulin resistance are inherently complex with their interrelation for
triggering the pathogenesis of diabetes also somewhat undefined. Both pathogenic states …
triggering the pathogenesis of diabetes also somewhat undefined. Both pathogenic states …
Beta cell hubs dictate pancreatic islet responses to glucose
NR Johnston, RK Mitchell, E Haythorne, MP Pessoa… - Cell metabolism, 2016 - cell.com
The arrangement of β cells within islets of Langerhans is critical for insulin release through
the generation of rhythmic activity. A privileged role for individual β cells in orchestrating …
the generation of rhythmic activity. A privileged role for individual β cells in orchestrating …
Decreased consumption of branched-chain amino acids improves metabolic health
Summary Protein-restricted (PR), high-carbohydrate diets improve metabolic health in
rodents, yet the precise dietary components that are responsible for these effects have not …
rodents, yet the precise dietary components that are responsible for these effects have not …
Expansion of islet-resident macrophages leads to inflammation affecting β cell proliferation and function in obesity
The nature of obesity-associated islet inflammation and its impact on β cell abnormalities
remains poorly defined. Here, we explore immune cell components of islet inflammation and …
remains poorly defined. Here, we explore immune cell components of islet inflammation and …
Inadequate β-cell mass is essential for the pathogenesis of type 2 diabetes
For patients with type 1 diabetes, it is accepted among the scientific community that there is
a marked reduction in β-cell mass; however, with type 2 diabetes, there is disagreement as …
a marked reduction in β-cell mass; however, with type 2 diabetes, there is disagreement as …
Pancreatic β cell dedifferentiation in diabetes and redifferentiation following insulin therapy
Diabetes is characterized by" glucotoxic" loss of pancreatic β cell function and insulin
content, but underlying mechanisms remain unclear. A mouse model of insulin-secretory …
content, but underlying mechanisms remain unclear. A mouse model of insulin-secretory …
Retracted: betatrophin: a hormone that controls pancreatic β cell proliferation
P Yi, JS Park, DA Melton - Cell, 2013 - cell.com
Replenishing insulin-producing pancreatic b cell mass will benefit both type I and type II
diabetics. In adults, pancreatic b cells are generated primarily by self-duplication. We report …
diabetics. In adults, pancreatic b cells are generated primarily by self-duplication. We report …
Pancreatic β cell regeneration as a possible therapy for diabetes
Diabetes is the result of having inadequate supply of functional insulin-producing β cells.
Two possible approaches for replenishing the β cells are:(1) replacement by transplanting …
Two possible approaches for replenishing the β cells are:(1) replacement by transplanting …
[HTML][HTML] Cell maturation: Hallmarks, triggers, and manipulation
How cells become specialized, or" mature," is important for cell and developmental biology.
While maturity is usually deemed a terminal fate, it may be more helpful to consider …
While maturity is usually deemed a terminal fate, it may be more helpful to consider …