Histamine is a transmitter in the nervous system and a signaling molecule in the gut, the
skin, and the immune system. Histaminergic neurons in mammalian brain are located …

Histamine-releasing neurons are located exclusively in the TM of the hypothalamus, from
where they project to practically all brain regions, with ventral areas (hypothalamus, basal …

Amygdala neuroplasticity has emerged as a candidate substrate for Pavlovian fear memory.
By this view, conditional stimulus (CS)-evoked activity represents a mnemonic code that …

The α7-selective agonists 3-(2, 4-dimethoxybenzylidene)-anabaseine (GTS-21), also known
as DMXB, and 3-(4-hydroxy, 2-methoxybenzylidene) anabaseine (4OH-GTS-21) produce a …

A few decades elapsed between the attribution of unwanted side effects of classic
antihistamine compounds to the blockade of central H1 receptors, and the acceptance of the …

Optogenetics—the use of light and genetics to manipulate and monitor the activities of
defined cell populations—has already had a transformative impact on basic neuroscience …

The basolateral amygdala (BLA) is involved in learning that certain environmental cues
predict threatening events. Several studies have shown that manipulation of …

The dorsolateral striatum (DLS) is the critical neural substrate that plays a role in motor
control and motor learning. Our past study revealed a direct histaminergic projection from …

In the present study we analyzed the effect of continuous intraventricular infusion of the
histamine H 1 receptor antagonist d-chlorpheniramine on the performance of 32-month-old …

The surprisingly beneficial effects in Alzheimer disease (AD) of ion channel blockers (ICB)
like memantine that act on NMDA-and other aminergic transmitter receptors are yet poorly …