Amorphous solid dispersions: role of the polymer and its importance in physical stability and in vitro performance

Q Shi, H Chen, Y Wang, R Wang, J Xu, C Zhang - Pharmaceutics, 2022 - mdpi.com
Amorphous solid dispersions stabilized by one or more polymer (s) have been widely used
for delivering amorphous drugs with poor water solubilities, and they have gained great …

Co-amorphous Drug Delivery Systems: a Review of Physical Stability, In Vitro and In Vivo Performance

Q Shi, Y Wang, SM Moinuddin, X Feng, F Ahsan - AAPS PharmSciTech, 2022 - Springer
Over the past few decades, co-amorphous solids have been used as a promising approach
for delivering poorly water-soluble drugs. Co-amorphous solids, comprising …

Improving physicochemical properties and pharmacological activities of ternary co-amorphous systems

X Fang, Y Hu, G Yang, W Shi, S Lu, Y Cao - European Journal of …, 2022 - Elsevier
The formation of co-amorphous by combining low molecular weight compounds with drugs
is a relatively new technology in the pharmaceutical field, which can significantly improve …

Role of supercritical CO2 impregnation variables on β-carotene loading into corn starch aerogel particles

ALB Dias, T Hatami, J Viganó, EJS de Araújo… - Journal of CO2 …, 2022 - Elsevier
Abstract β-carotene is a natural dye with antioxidant and provitamin A activities, which has
essential roles in human health. However, its direct use in food products is unviable since it …

Hydroxypropyl-β-cyclodextrin-based solid dispersed granules: A prospective alternative to conventional solid dispersion

JS Kim, F ud Din, YJ Choi, MR Woo, S Cheon… - International Journal of …, 2022 - Elsevier
The purpose of the present study was to develop hydroxypropyl-β-cyclodextrin (HP-β-CD)-
based solid dispersed granules as a superior system to solid dispersion. The solid …

Introduction to Pharmaceutical Co-amorphous Systems Using a Green Co-milling Technique

JFC Silva, MTS Rosado, TMR Maria… - Journal of chemical …, 2023 - ACS Publications
The concept of co-amorphous systems is introduced in an integrated laboratory experiment,
designed for advanced chemistry students, using solvent-free, environmentally friendly …

Formulation of nitrendipine/hydroxypropyl-β-cyclodextrin inclusion complex as a drug delivery system to enhance the solubility and bioavailability by supercritical fluid …

B Liang, J Hao, N Zhu, L Han, L Song, H Hong - European Polymer Journal, 2023 - Elsevier
In this study, the solution enhanced dispersion by supercritical fluids (SEDS) technology was
applied to prepare inclusion complex with hydroxypropyl-β-cyclodextrin (HP-β-CD) as …

Fused Deposition Modelling 3D printing and solubility improvement of BCS II and IV active ingredients–A narrative review

A Roche, NM Sanchez-Ballester, B Bataille… - Journal of Controlled …, 2024 - Elsevier
In the field of pharmaceutical research and development, Fused Deposition Modelling
(FDM) 3D printing (3DP) has aroused growing interest within the last ten years. The use of …

Evaluating spray gelation and spray freeze drying as the granulation method to prepare oral tablets of amorphous drug nanoplex

A Chua, HT Ng, WS Cheow, K Hadinoto - Advanced Powder Technology, 2023 - Elsevier
Amorphous drug nanoplex represents one of the most promising solubility enhancement
strategies of poorly-soluble drugs. Solubility enhancement capability of nanoplex hitherto …

Mesoporous Drug Delivery System: From Physical Properties of Drug in Solid State to Controlled Release

Y Wang, F Li, J **n, J Xu, G Yu, Q Shi - Molecules, 2023 - mdpi.com
Mesoporous materials, which exhibit great potential in the control of polymorphs and
delivery of poorly water-soluble drugs, have obtained considerable attention in the field of …