Technical advances in neuroimaging, notably in fMRI, have allowed distributed patterns of
functional connectivity to be mapped in the human brain with increasing spatiotemporal …

There are currently no pharmacological treatments available that completely halt or reverse
the progression of Parkinson's Disease (PD). Hence, there is an unmet need for …

The default mode network (DMN) is critical for self-referential mental processes, and its
dysfunction is implicated in many neuropsychiatric disorders. However, the …

Ventral tegmental area (VTA) dopamine neurons regulate reward-related associative
learning and reward-driven motivated behaviors, but how these processes are coordinated …

Altered or atypical functional connectivity as measured with functional magnetic resonance
imaging (fMRI) is a hallmark feature of brain connectopathy in psychiatric, developmental …

Background Imbalanced synaptic transmission appears to be an early driver in Alzheimer's
disease (AD) leading to brain network alterations. Early detection of altered synaptic …

The key element of dopamine (DA) neurotransmission is undoubtedly DA transporter (DAT),
a transmembrane protein responsible for the synaptic reuptake of the mediator. Changes in …

Memory consolidation after learning involves spontaneous, brain-wide network
reorganization during rest and sleep, but how this is achieved is still poorly understood …

The basal forebrain cholinergic neurons provide acetylcholine to the cortex via large
projections. Recent molecular imaging work in humans indicates that the cortical cholinergic …

Amyloid accumulation in Alzheimer's disease (AD) is associated with synaptic damage and
altered connectivity in brain networks. While measures of amyloid accumulation and …